淨住 大慈 Daiji Kiyozumi

自己紹介 / Personal Data

趣味・特技 / What I Like

やりたいこと100個リストを作ってひとつずつ消化していくこと

To list up 100 things I want to do every year, and to do them one by one.

研究テーマ / Research Interests

生殖における細胞外環境の機能解明

Physiological function of extracellular environment in mammalian reproduction

キーワード / Keywords

細胞外マトリックス

Extracellular matrix

メッセージ / Messages

2014年10月から伊川研に異動しました。これまで器官形成における細胞外マトリックスの役割について研究してきたので、この経験を生かして細胞外環境という観点から生殖の分子機構解明に取り組んでいます。伊川研は個性的な学生×多様なバックグラウンドを持つスタッフ×ポジティブでユーモアに溢れたPIが力を合わせて大きなシナジーを生み出せるところが好きです。

I am studying in Ikawa's Lab since Oct. 2014. As I have been studying on the function of ECMs in organogenesis, in Ikawa's Lab I want to clarify the importance of extracellular environment in mammalian reproduction with my ECM research experiences. I like Ikawa's Lab because our lab can generate a great synergism with cooperation between lab members.

論文 / Publications

【原著論文】

1. Kiyozumi, D., Taniguchi, Y., Nakano, I., Toga, J., Yagi, E., Hasuwa, H., Ikawa, M., Sekiguchi, K., 2018. Laminin γ1 C-terminal Glu-to-Gln mutation induces early post-implantation lethality. Life Science Alliance, 1, e201800064, doi: 10.26508/lsa.201800064
2. Muto, M., Fujihara, Y., Tobita, T., Kiyozumi, D., Ikawa, M., 2016. Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice. Biol. Reprod. 94, 6. doi:10.1095/biolreprod.115.133454
3. Miyata, H., Castaneda, J.M., Fujihara, Y., Yu, Z., Archambeault, D.R., Isotani, A., Kiyozumi, D., Kriseman, M.L., Mashiko, D., Matsumura, T., Matzuk, R.M., Mori, M., Noda, T., Oji, A., Okabe, M., Prunskaite-Hyyrylainen, R., Ramirez-Solis, R., Satouh, Y., Zhang, Q., Ikawa, M., Matzuk, M.M., 2016. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc. Natl. Acad. Sci. U. S. A. 113, 7704-10. doi:10.1073/pnas.1608458113
4. Jeong, S.-J., Luo, R., Singer, K., Giera, S., Kreidberg, J., Kiyozumi, D., Shimono, C., Sekiguchi, K., Piao, X., 2013. GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development. PLoS One 8, e68781. doi:10.1371/journal.pone.0068781
5. Sato-Nishiuchi, R., Nakano, I., Ozawa, A., Sato, Y., Takeichi, M., Kiyozumi, D., Yamazaki, K., Yasunaga, T., Futaki, S., Sekiguchi, K., 2012. Polydom/SVEP1 is a ligand for integrin α9β1. J. Biol. Chem. 287, 25615-30. doi:10.1074/jbc.M112.355016
6. Kiyozumi, D., Takeichi, M., Nakano, I., Sato, Y., Fukuda, T., Sekiguchi, K., 2012. Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins. J. Cell Biol. 197, 677-89. doi:10.1083/jcb.201203065
7. Vissers, L.E.L.M., Cox, T.C., Maga, a M., Short, K.M., Wiradjaja, F., Janssen, I.M., Jehee, F., Bertola, D., Liu, J., Yagnik, G., Sekiguchi, K., Kiyozumi, D., van Bokhoven, H., Marcelis, C., Cunningham, M.L., Anderson, P.J., Boyadjiev, S. a, Passos-Bueno, M.R., Veltman, J. a, Smyth, I., Buckley, M.F., Roscioli, T., 2011. Heterozygous mutations of FREM1 are associated with an increased risk of isolated metopic craniosynostosis in humans and mice. PLoS Genet. 7, e1002278. doi:10.1371/journal.pgen.1002278
8. Kiyozumi, D., Osada, A., Sugimoto, N., Weber, C.N., Ono, Y., Imai, T., Okada, A., Sekiguchi, K., 2011. Identification of genes expressed during hair follicle induction. J. Dermatol. 38, 674-9. doi:10.1111/j.1346-8138.2010.01050.x
9. Kiyozumi, D., Nakano, I., Takahashi, K.L., Hojo, H., Aoyama, H., Sekiguchi, K., 2011. Fused pulmonary lobes is a rat model of human Fraser syndrome. Biochem. Biophys. Res. Commun. 411, 440-4. doi:10.1016/j.bbrc.2011.06.174
10. Manabe, R. -i., Tsutsui, K., Yamada, T., Kimura, M., Nakano, I., Shimono, C., Sanzen, N., Furutani, Y., Fukuda, T., Oguri, Y., Shimamoto, K., Kiyozumi, D., Sato, Y., Sado, Y., Senoo, H., Yamashina, S., Fukuda, S., Kawai, J., Sugiura, N., Kimata, K., Hayashizaki, Y., Sekiguchi, K., 2008. Transcriptome-based systematic identification of extracellular matrix proteins. Proc. Natl. Acad. Sci. U. S. A. 105, 12849-12854. doi:10.1073/pnas.0803640105
11. Kiyozumi, D., Sugimoto, N., Nakano, I., Sekiguchi, K., 2007. Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1. Matrix Biol. 26, 456-462.
12. Kiyozumi, D., Sugimoto, N., Sekiguchi, K., 2006. Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc. Natl. Acad. Sci. U. S. A., 11981-11986.
13. Kiyozumi, D., Osada, A., Sugimoto, N., Weber, C.N., Ono, Y., Imai, T., Okada, A., Sekiguchi, K., 2005. Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle. Exp. Cell Res. 306, 9-23. doi:10.1016/j.yexcr.2005.01.020
14. Osada, A., Kiyozumi, D., Tsutsui, K., Ono, Y., Weber, C.N., Sugimoto, N., Imai, T., Okada, A., Sekiguchi, K., 2005. Expression of MAEG, a novel basement membrane protein, in mouse hair follicle morphogenesis. Exp.Cell Res. 303, 148-159.
15. Kiyozumi, D., Ishimizu, T., Nakanishi, T., Norioka, S., 2002. Pollen UDP-glucose pyrophosphorylase showing polymorphism well-correlated to the S genotype of Pyrus pyrifolia. Sex. Plant Reprod. 14, 315-323. doi:10.1007/s00497-001-0125-1
16. Kiyozumi, D., Ishimizu, T., Nakanishi, T., Sakiyama, F., Norioka, S., 1999. Molecular Cloning and Nucleotide Sequencing of a cDNA Encoding UDP-Glucose Pyrophosphorylase of Japanese Pear (Accession No. AB013353). Plant Physiol. 119, 364.

【総説】

1. Tobita, T., Kiyozumi, D., Ikawa, M., 2017. Placenta-specific gene manipulation using lentiviral vector and its application. Placenta 1-7. doi:10.1016/j.placenta.2017.09.012
2. Kiyozumi, D., Sato-Nishiuchi, R., Sekiguchi, K., 2014. In situ detection of integrin ligands. Curr. Protoc. Cell Biol. 65, 10.19.1-10.19.17. doi:10.1002/0471143030.cb1019s65
3. 淨住大慈、関口清俊. 基底膜のカスタマイゼーションとその器官形成における役割. THE LUNG perspectives 第15巻3号 336-340. 2007年
4. 淨住大慈、関口清俊. 最適化された細胞外環境を提供する細胞外マトリックス. 実験医学 第23巻1号 52-57. 2005年