ASPIRE R5年度-9年度先端国際共同研究推進プログラム 次世代生殖補助医療に資する国際共同研究 International Collaborative Research Pioneering Next-Generation Assisted Reproductive Medicine

研究業績Achievements

R7年度/FY2025

  1. An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling
    #Hiraoka T, Aikawa S, Mashiko D, Nakagawa T, Shirai H, Hirota Y, Kimura H, #Ikawa M
    Nat Commun. 2025 Jul 1;16(1):5755. doi: 10.1038/s41467-025-60610-x.
    https://pubmed.ncbi.nlm.nih.gov/40595542/
     
  2. Compensation for X-linked Pdha1 silencing by Pdha2 is essential for meiotic double-strand break repair in spermatogenesis
    Pan C, #Shimada K, Chang HY, Wang H, #Ikawa M 
    Development. 2025 Jul 18:dev.204683. doi: 10.1242/dev.204683. Online ahead of print.
    https://pubmed.ncbi.nlm.nih.gov/40679056/
     
  3. Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13
    Lu Y, Ikawa M, #Tang S
    Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2425952122. doi: 10.1073/pnas.2425952122. Epub 2025 Mar 5.
    https://pubmed.ncbi.nlm.nih.gov/40042902/
     
  4. TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice
    *Kaneda Y, #*Lu Y, *Sun J, Shimada K, Emori C, Noda T, Koyano T, Matsuyama M, #Miyata H, #Ikawa M
    Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2417943122. doi: 10.1073/pnas.2417943122. Epub 2025 Mar 3.
    https://pubmed.ncbi.nlm.nih.gov/40030029/
     
  5. Cdkn1c orchestrates a molecular network that regulates euploidy of male mouse germline stem cells
    #Kanatsu-Shinohara M, Yamamoto T, Liu T, Nakayama KI, Shinohara T​​​​​.
    Development. 2025 Feb 15;152(4):dev204286. doi: 10.1242/dev.204286. Epub 2025 Feb 24.
    https://pubmed.ncbi.nlm.nih.gov/39850012/​​​​​​​
     
  6. Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice
    Qiu Y, #Shimada K , Yamamoto K , #Ikawa M
    Biol Reprod. 2025 Jan 14;112(1):169-178. doi: 10.1093/biolre/ioae137.
    https://pubmed.ncbi.nlm.nih.gov/39292630/
    ​​​​​​​
  7. Trophectoderm-specific gene manipulation using adeno-associated viral vectors
    Nakagawa T, Emori C,＃Ikawa M​​​
    Exp Anim. 2025 Jan 11. doi: 10.1538/expanim.24-0165. Online ahead of print.
    https://pubmed.ncbi.nlm.nih.gov/39805595/
     
  8. Development of the membrane ceiling method for in vitro spermatogenesis
    Kamoshita M, Shirai H, Nakamura H, Kishimoto T, Hatanaka Y, Mashiko D, Esashika K, Yang J, Yamasaki S, Ogawa T, #Kimura H, #Ikawa M.
    Sci Rep. 2025 Jan 3;15(1):625. doi: 10.1038/s41598-024-84965-1.
    https://pubmed.ncbi.nlm.nih.gov/3975388

後日掲載予定

招待

Date Kind Presenters Place Conference Title
  招待講演        
4/3 招待講演 Masahito Ikawa USA Tri-Repro Symposium 2025 Testis-enriched genes and their functions during spermatogenesis and fertilization
4/2 招待講演 Masahito Ikawa USA 第2回ASPIRE meeting International Collaborative Research Pioneering Next Generation Assisted Reproductive Medicine

 

応募

Date Kind Presenters Place Conference Title
7/30-31 Poster Haruhiko MIYATA、Yuki OYAMA、Kentaro SHIMADA、Rie IIDA-NORITA、Chihiro EMORI、Maki KAMOSHITA、Seiya OURA、Ryohei KATAYAMA、Martin M MATZUK、Masahito IKAWA New Hampshire, USA Fertilization and Activation of Development(GRC Fertilization)

Inhibition of ROS1 activity with lorlatinib reversibly suppresses male fertility in mice
7/28-29 Poster Rie Iida-Norita, Haruhiko Miyata, Akinori Ninomiya, Chihiro Emori, Maki Kamoshita, Chen Pan, Haoting Wang,and Masahito Ikawa USA Fertilization and Activation of Development(GRC Fertilization) Essential Modulator of sperm-specific Na+/H+ exchanger complex: Implications for Sperm Motility and Male Fertility in mice
7/28-29 Poster Yuki Kaneda, Yonggang Lu, Jiang Sun, Keisuke Shimada, Chihiro Emori, Taichi Noda, Takayuki Koyano,  Makoto Matsuyama, Haruhiko Miyata, Masahito Ikawa New Hampshire, USA Fertilization and Activation of Development(GRC Fertilization) TEX38/ZDHHC19 complex regulates sperm head morphogenesis and is essential for male fertility in mice
5/16 Oral Ryo Yokomizo USA PennVERGE mini-symposium Availability of xenogeneic reconstituted testes in in vitro spermatogenesis
4/26-29 Oral Ryo Yokomizo USA  IFFS2025 World Congress/JSRM70 Generation of spermatogonia from induced pluripotent stem cells in humans and non-human primates

4/27

 Poster Sohei Kuribayashi USA AUA 2025 Effects of Declining Testosterone on Visceral Fat Accumulation and the Mitigating Role of Regular Exercise 

4/26

 Oral Sohei Kuribayashi USA AUA 2025 Role of Intratesticular Creatine in Regulating the Blood-Testis Barrier and Its Impact on Spermatogenesis
4/3 Poster Yuki Hatanaka USA Tri-Repro Symposium 2025 Induction of in vitro mouse spermatozoa and an overview of the evaluation
4/3 Poster Ryo Yokomizo USA Tri-Repro Symposium 2025 Directed differentiation of human induced pluripotent stem cells gives rise to spermatogonia and differentiating germ cells
4/2 Oral Sohei Kuribayashi USA 第2回ASPIRE meeting Creatine as a Key Molecule in Testicular Function and Imaging Development
           

招待

Date Kind Presenters Place Conference Title
7/17 招待講演 Seiya Oura 国内 理研開拓研究所 セミナー What We Build, We Start to Understand: Modeling Human Embryos with Stem Cells
7/15 招待講演 Seiya Oura 国内 熊本大学発生医学研究所 セミナー What We Build, We Start to Understand: Modeling Human Embryos with Stem Cells
7/12 招待講演 嶋田圭祐 北海道 第21回北海道実験動物研究会学術集会 遺伝子改変マウスを用いた精子形成メカニズムの解析
7/7 招待講演 Seiya Oura 国内 理研 BDRセミナー What We Build, We Start to Understand: Modeling Human Embryos with Stem Cells
6/20 招待講演 嶋田圭祐 国内 日本アンドロロジー学会第44回学術大会 TSKSは精子細胞内のnuageに局在し、細胞質内内容物の除去に関わることで流線型の精子形成を可能にする
6/14 招待講演 宮田 治彦 北海道 ジオラマ若手勉強会in女川 遺伝子改変マウスを用いた精子機能の解析
4/27 招待講演 伊川正人 国内 日本生殖医学会学術講演会 ゲノム編集アプローチを用いた精子形成の理解と新規生殖補助医療開発

 

応募

Date Kind Presenters Place Conference Title
7/23 Oral
Hiroaki Kitakaze, Haruhiko Miyata, Masahito Ikawa  
金沢市 第7回がん研若手コロキウム・学際科学若手コロキウム KIF2C deletion causes meiotic abnormalities and non-obstructive azoospermia in mice
7/10 Poster Yumiao Qiu 国内 第53回 内藤コンファレンス CCDC188 is essential for sperm head-neck connection during spermiogenesis and male fertility in mice
7/10 Poster Haruhiko MIYATA 国内 第53回 内藤コンファレンス Inhibition of ROS1 activity with lorlatinib reversibly suppresses male fertility in mice
7/9 Poster Daisuke Mashiko 国内 第53回 内藤コンファレンス SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice
6/21 Poster 飯田理恵 国内 日本アンドロロジー学会第44回学術大会 新規膜貫通型タンパク質による精子cAMP産生の制御
6/20 Poster 増子大輔 国内 日本アンドロロジー学会第44回学術大会 SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice
6/20 Poster 宮田 治彦 国内 日本アンドロロジー学会第44回学術大会 ロルラチニブによるROS1活性阻害は雄マウスの生殖能力を可逆的に抑制する
6/20 Oral 鴨下真紀 国内 日本アンドロロジー学会第44回学術大会 新規精巣組織培養デバイスの開発
6/19 Poster 久保直樹 国内 第18回日本エピジェネティクス研究会年会 ヒストン修飾とゲノム３次元構造それぞれが関与する細胞分化過程の転写制御機構
6/17 Poster 藤内慎梧 国内 日本ゲノム編集学会第１０回大会 新規膜貫通型タンパク質による精子cAMP産生の制御

  1. ISA Young Andrologist Award　Keisuke Shimada（伊川G）

  1. （有料会員限定記事）
    伊川　正人
    日経新聞 （令和７年３月２５日）