I’d like to thank the members of the Ikawa lab for their input and contributions to this paper. For over 20 years, TCP11 had been localized to mature sperm where it was thought to function in the cAMP pathway; however, our work clearly demonstrates that this is not the case. Through rigorous analysis and interpretation of the data, we showed that TCP11 functions in the spermatozoa of the testis and not in mature sperm. We hope our work begins to clarify the function of this gene, and that future work can determine whether this gene can explain some of the infertility seen in men.
(By Julio)
Mouse T-complex protein 11 is important for progressive motility in sperm.
https://www.ncbi.nlm.nih.gov/pubmed/31837139