Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model
*Ito S, *Oyama Y, Yuasa T, Amano K, Onishi K, Izumi A, Jun AS, Ikawa M, Koizumi N, #Okumura N. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):19. doi: 10.1167/iovs.66.4.19. https://pubmed.ncbi.nlm.nih.gov/40197778/
Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy.
Fujimoto S, Endo M, Tonomura S, Tsuji F, Haraguchi H, Hasegawa K, Numao T, Izumi A, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Oyama Y, Ikawa M, Jun AS, Koizumi N, #Okumura N. Cells. 2025 Mar 27;14(7):498. doi: 10.3390/cells14070498. https://pubmed.ncbi.nlm.nih.gov/40214452/
Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.
Lu Y, Ikawa M, #Tang S. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2425952122. doi: 10.1073/pnas.2425952122. Epub 2025 Mar 5. https://pubmed.ncbi.nlm.nih.gov/40042902/
TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice
*Kaneda Y, #*Lu Y, *Sun J, Shimada K, Emori C, Noda T, Koyano T, Matsuyama M, #Miyata H, #Ikawa M. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2417943122. doi: 10.1073/pnas.2417943122. Epub 2025 Mar 3. https://pubmed.ncbi.nlm.nih.gov/40030029/
Trophectoderm-specific gene manipulation using adeno-associated viral vectors
Nakagawa T, Emori C,＃Ikawa M. Exp Anim. 2025 Jan 11. doi: 10.1538/expanim.24-0165. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39805595/
Development of the membrane ceiling method for in vitro spermatogenesis
Kamoshita M, Shirai H, Nakamura H, Kishimoto T, Hatanaka Y, Mashiko D, Esashika K, Yang J, Yamasaki S, Ogawa T, #Kimura H, #Ikawa M. Sci Rep. 2025 Jan 3;15(1):625. doi: 10.1038/s41598-024-84965-1. https://pubmed.ncbi.nlm.nih.gov/39753886