An ex vivo uterine system captures implantation, embryogenesis, and trophoblast invasion via maternal-embryonic signaling
#Hiraoka T, Aikawa S, Mashiko D, Nakagawa T, Shirai H, Hirota Y, Kimura H & #Ikawa M. Nat Commun. 2025 Jul 1;16(1):5755. doi: 10.1038/s41467-025-60610-x. https://pubmed.ncbi.nlm.nih.gov/40595542/
Deep-learning-based automated prediction of mouse seminiferous tubule stage by using bright-field microscopy
Tokuoka Y, Endo T, Morikura T, Hiradate Y, Ikawa M, Funahashi A. Sci Rep. 2025 Jul 1;15(1):21849. doi: 10.1038/s41598-025-06727-x. https://pubmed.ncbi.nlm.nih.gov/40594622/
CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice
Ogawa Y, #Lu Y, Kiyozumi D, Chang HY, #Ikawa M. Andrology. 2025 Jul;13(5):1251-1260. doi: 10.1111/andr.13564. Epub 2023 Dec 12. https://pubmed.ncbi.nlm.nih.gov/38084666/
Mouse genome engineering uncovers 18 genes dispensable for male reproduction
Chang H, #Lu Y, Yamamoto K, Sun J, Shimada K, Hiradate Y, Fujihara Y, #Ikawa M Andrology. 2025 Jun 26. doi: 10.1111/andr.70088. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/40572022/
Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene
Oyama Y, Ito S, Yuasa T, Ueda M, Chiba S, Nakagawa T, Izumi A, #Ikawa M, Koizumi N, #Okumura N. Invest Ophthalmol Vis Sci. 2025 Jun 2;66(6):18. doi: 10.1167/iovs.66.6.18. https://pubmed.ncbi.nlm.nih.gov/40465262/
KIF2C Deletion Causes Meiotic Abnormalities and Nonobstructive Azoospermia in Mice
Kitakaze H, #Miyata H, Oyama Y, Pan C, Kujime Y, Tsujimura G, Imanaka T, Kuribayashi S, Ueda N, Takezawa K, Fukuhara S, Nonomura N, #Ikawa M. Reprod Med Biol. 2025 May 27;24(1):e12659. doi: 10.1002/rmb2.12659. eCollection 2025 Jan-Dec. https://pubmed.ncbi.nlm.nih.gov/40433108/
SLC35G3 is a UDP-N-acetylglucosamine transporter for sperm glycoprotein formation and underpins male fertility in mice
Mashiko D, Tonai S, Miyata H, Matzuk MM, #Ikawa M. bioRxiv[Preprint]. 2025 May 15:2025.05.12.653469. doi: 10.1101/2025.05.12.653469. https://pubmed.ncbi.nlm.nih.gov/40462929/
Zinc is a Key Regulator of the Sperm-Specific K+ Channel (Slo3) Function
Andriani RT, Pipatpolkai T, Miyata H, Ikawa M, Okamura Y, #Kawai T. eLife https://doi.org/10.7554/eLife.105450.1 https://elifesciences.org/reviewed-preprints/105450v1
The absence of both RIBC1 and RIBC2 induces decreased sperm motility and litter size in male mice #Katsuma K, Shimada K, Tonai S, Mashiko D, Iida-Norita R, Kaneda Y, Miyata H, #Ikawa M. Andrology. 2025 Apr 23. doi: 10.1111/andr.70045. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/40265983/
Heterozygous Tcf4 Deficiency Mitigates Fuchs Endothelial Corneal Dystrophy Progression in a Mouse Model
*Ito S, *Oyama Y, Yuasa T, Amano K, Onishi K, Izumi A, Jun AS, Ikawa M, Koizumi N, #Okumura N. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):19. doi: 10.1167/iovs.66.4.19. https://pubmed.ncbi.nlm.nih.gov/40197778/
Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy.
Fujimoto S, Endo M, Tonomura S, Tsuji F, Haraguchi H, Hasegawa K, Numao T, Izumi A, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Oyama Y, Ikawa M, Jun AS, Koizumi N, #Okumura N. Cells. 2025 Mar 27;14(7):498. doi: 10.3390/cells14070498. https://pubmed.ncbi.nlm.nih.gov/40214452/
Retraction for Hiramatsu et al., "The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model"
Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, #Horiguchi Y. mBio. 2025 Mar 12;16(3):e0392124. doi: 10.1128/mbio.03921-24. Epub 2025 Feb 5. https://pubmed.ncbi.nlm.nih.gov/39907486/
Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13.
Lu Y, Ikawa M, #Tang S. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2425952122. doi: 10.1073/pnas.2425952122. Epub 2025 Mar 5. https://pubmed.ncbi.nlm.nih.gov/40042902/
TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice
*Kaneda Y, #*Lu Y, *Sun J, Shimada K, Emori C, Noda T, Koyano T, Matsuyama M, #Miyata H, #Ikawa M. Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2417943122. doi: 10.1073/pnas.2417943122. Epub 2025 Mar 3. https://pubmed.ncbi.nlm.nih.gov/40030029/
Immunogenicity and safety of a live-attenuated SARS-CoV-2 vaccine candidate based on multiple attenuation mechanisms.
Okutani MS, Okamura S, Gis T, Sasaki H, Lee S, Kashiwabara A, Goto S, Matsumoto M, Yamawaki M, Miyazaki T, Nakagawa T, Ikawa M, Kamitani W, Takekawa S, Yamanishi K, #Ebina H. Elife. 2025 Feb 11:13:RP97532. doi: 10.7554/eLife.97532. https://pubmed.ncbi.nlm.nih.gov/39932490/
Ccer1 is a spermatid-specific gene required for spermatogenesis and male fertility.
Sammer B, Schmid P, Miyata H, Kazi S, Honkimaa AL, Petrov P, Kapiainen E, Miinalainen l, Izzi V, Ikawa M, Prunskaite-Hyyryläinen R. Int J Dev Biol. 2024;68(4):251-262. doi: 10.1387/ijdb.240205rp. https://pubmed.ncbi.nlm.nih.gov/39868420/
Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice†
Qiu Y, #Shimada K, Yamamoto K, #Ikawa M. Biol Reprod. 2025 Jan 14;112(1):169-178. doi: 10.1093/biolre/ioae137. https://pubmed.ncbi.nlm.nih.gov/39292630/
Trophectoderm-specific gene manipulation using adeno-associated viral vectors
Nakagawa T, Emori C,＃Ikawa M. Exp Anim. 2025 Jan 11. doi: 10.1538/expanim.24-0165. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39805595/
Development of the membrane ceiling method for in vitro spermatogenesis
Kamoshita M, Shirai H, Nakamura H, Kishimoto T, Hatanaka Y, Mashiko D, Esashika K, Yang J, Yamasaki S, Ogawa T, #Kimura H, #Ikawa M. Sci Rep. 2025 Jan 3;15(1):625. doi: 10.1038/s41598-024-84965-1. https://pubmed.ncbi.nlm.nih.gov/39753886