Gelsolin alleviates rheumatoid arthritis by negatively regulating NLRP3 inflammasome activation.
Lee J, Sasaki F, Koike E, Cho M, Lee Y, Dho SH, Lee J, Lee E, Toyohara E, Sunakawa M, Ishibashi M, Hung HH, Nishioka S, Komine R, Okura C, Shimizu M, Ikawa M, Yoshimura A, #Morita R, #Kim LK. Cell Death Differ. 2024 Dec;31(12):1679-1694. doi: 10.1038/s41418-024-01367-6. Epub 2024 Aug 24. https://pubmed.ncbi.nlm.nih.gov/39179640/
Intratesticular creatine maintains spermatogenesis by defining tight junctions.
Kuribayashi S, #Fukuhara S, Kitakaze H, Tsujimura G, Imanaka T, Ueda N, Takezawa K, Ikawa M, Nonomura N. Sci Rep. 2024 Dec 28;14(1):30692. doi: 10.1038/s41598-024-77986-3. https://pubmed.ncbi.nlm.nih.gov/39730393/
A conserved fertilization complex bridges sperm and egg in vertebrates. #Deneke VE, *Blaha A, Lu Y, Suwita JP, Draper JM, Phan CS, Panser K, Schleiffer A, Jacob L, Humer T, Stejskal K, Krssakova G, Roitinger E, Handler D, Kamoshita M, Vance TDR, Wang X, Surm JM, Moran Y, Lee JE, Ikawa M, #Pauli A. Cell. 2024 Dec 12;187(25):7066-7078.e22. doi: 10.1016/j.cell.2024.09.035. Epub 2024 Oct 17. https://pubmed.ncbi.nlm.nih.gov/39423812/
Age-associated aberrations of the cumulus-oocyte interaction and in the zona pellucida structure reduce fertility in female mice
Ishikawa-Yamauchi Y, Emori C, Mori H, Endo T, Kobayashi K, Watanabe Y, Sagara H, Nagata T, Motooka D, Ninomiya A, Ozawa M, #Ikawa M. Commun Biol. 2024 Dec 24;7(1):1692. doi: 10.1038/s42003-024-07305-z. https://pubmed.ncbi.nlm.nih.gov/39719529/
Multiple lines of evidence for disruption of nuclear lamina and nucleoporins in FUS amyotrophic lateral sclerosis.
Okada K, #Ito D, Morimoto S, Kato C, Oguma Y, Warita H, Suzuki N, Aoki M, Kuramoto J, Kobayashi R, Shinozaki M, Ikawa M, Nakahara J, Takahashi S, Nishimoto Y, Shibata S, #Okano H. Brain. 2024 Nov 4;147(11):3933-3948. doi: 10.1093/brain/awae224 https://pubmed.ncbi.nlm.nih.gov/39312484/
Spatiotemporal functions of leukemia inhibitory factor in embryo attachment and implantation chamber formation.
*Aikawa S, *Hiraoka T, Matsuo M, Fukui Y, Fujita H, Saito-Fujita T, Shimizu-Hirota R, Takeda N, Hiratsuka D, He X, Ishizawa C, Iida R, Akaeda S, Harada M, Wada-Hiraike O, Ikawa M, Osuga Y, #Hirota Y. Cell Death Discov. 2024 Nov 25;10(1):481. doi: 10.1038/s41420-024-02228-4. https://pubmed.ncbi.nlm.nih.gov/39587062/
Inhibition of ROS1 activity with lorlatinib reversibly suppresses fertility in male mice.
Oyama Y, Shimada K, #Miyata H, Iida-Norita R, Emori C, Kamoshita M, Oura S, Katayama R, Matzuk MM, #Ikawa M. Andrology. 2024 Nov 20. doi: 10.1111/andr.13808. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39568175/
Kdm4d mutant mice show impaired sperm motility and subfertility.
Xu Z, Fujimoto Y, Sakamoto M, Ito D, Ikawa M, Ishiuchi T. J Reprod Dev. 2024 Oct 1;70(5):320-326. doi: 10.1262/jrd.2024-039. Epub 2024 Jul 22. https://pubmed.ncbi.nlm.nih.gov/39034148/
Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.
*Nakanishi Y, *Izumi M, Matsushita H, Koyama Y, Diez D, Takamatsu H, Koyama S, Nishide M, Naito M, Mizuno Y, Yamaguchi Y, Mae T, Noda Y, Nakaya K, Nojima S, Sugihara F, Okuzaki D, Ikawa M, Shimada S, #Kang S, #Kumanogoh A. Neuron. 2024 Sep 4;112(17):2955-2972.e9. doi: 10.1016/j.neuron.2024.06.017. Epub 2024 Jul 12. https://pubmed.ncbi.nlm.nih.gov/39002542/
Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.
Kawaguchi T, Hashimoto M, Nakagawa R, Minami R, Ikawa M, #Nakayama JI, #Ueda J. Sci Rep. 2024 Sep 12;14(1):21305. doi: 10.1038/s41598-024-72362-7. https://pubmed.ncbi.nlm.nih.gov/39266663/
USF2 and TFEB compete in regulating lysosomal and autophagy genes.
*Kim J, *Yu YS, Choi Y, Lee DH, Han S, Kwon J, Noda T, Ikawa M, Kim D, Kim H, Ballabio A, #Kim Kl, #Baek SH. Nat Commun. 2024 Sep 27;15(1):8334. doi: 10.1038/s41467-024-52600-2. https://pubmed.ncbi.nlm.nih.gov/39333072/
Loss of CCDC188 causes male infertility with defects in the sperm head-neck connection in mice
Qiu Y, #Shimada K , Yamamoto K , #Ikawa M. Biol Reprod. 2024 Sep 18:ioae137. doi: 10.1093/biolre/ioae137. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39292630/
The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. #Kawai T, Morioka S, Miyata H, Andriani RT, Akter S, Toma G, Nakagawa T, Oyama Y, Iida-Norita R, Sasaki J, Watanabe M, Sakimura K, Ikawa M, Sasaki T, Okamura Y. Nat Commun. 2024 Aug 24;15(1):7289. doi: 10.1038/s41467-024-51755-2. https://pubmed.ncbi.nlm.nih.gov/39181879/
The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. #Kawai T, Morioka S, Miyata H, Andriani RT, Akter S, Toma G, Nakagawa T, Oyama Y, Iida-Norita R, Sasaki J, Watanabe M, Sakimura K, Ikawa M, Sasaki T, Okamura Y. Nat Commun. 2024 Aug 24;15(1):7289. doi: 10.1038/s41467-024-51755-2. https://pubmed.ncbi.nlm.nih.gov/39181879/
FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility
KanedaY, #Miyata H, Xu Z , ShimadaK, Kamoshita M, Nakagawa T, Emori C, #Ikawa M. Elife. 2024 Aug 20:13:RP92794. doi: 10.7554/eLife.92794. https://pubmed.ncbi.nlm.nih.gov/39163107/
Eighteen genes primarily expressed in the testis are not required for male fertility in mice
Yamamoto K, #Hiradate Y , #Ikawa M. Biol Reprod. 2024 Aug 6:ioae119. doi: 10.1093/biolre/ioae119. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39105275/
MYCBPAP is a central apparatus protein required for centrosome-nuclear envelope docking and sperm tail biogenesis in mice
*Wang H, *Kobayashi H, Shimada K, Oura S, Oyama Y, Kitakaze H, Noda T, Yabuta N, #Miyata H, #Ikawa M. J Cell Sci. 2024 Aug 2:jcs.261962. doi: 10.1242/jcs.261962. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/39092789/
Development of functional spermatozoa in mammalian spermiogenesis. *#Miyata H, *Shimada K, Kaneda Y, #Ikawa M. Development. 2024 Jul 15;151(14):dev202838. doi: 10.1242/dev.202838. https://pubmed.ncbi.nlm.nih.gov/39036999/
Conditional deficiency of Rho‐associated kinases disrupts endothelial cell junctions and impairs respiratory function in adult mice
*Akamine T, *Terabayashi T, Sasaki T, Hayashi R, Abe I, Hirayama F, Nureki SI, Ikawa M, Miyata H, Tokunaga A, Kobayashi T, Hanada K, Thumkeo D, Narumiya S, #Ishizaki T. FEBS Open Bio. 2024 Jun;14(6):906-921. doi: 10.1002/2211-5463.13802. Epub 2024 Apr 11. https://pubmed.ncbi.nlm.nih.gov/38604990/
Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP. #Miyazaki H, Nishioka S, Yamanaka T, Abe M, Imamura Y, Miyasaka T, Kakuda N, Oohashi T, Shimogori T, Yamakawa K, Ikawa M, #Nukina N. Transgenic Res. 2024 Jun;33(3):99-117. doi: 10.1007/s11248-024-00382-0. Epub 2024 Apr 29. https://pubmed.ncbi.nlm.nih.gov/38684589/
Golgi associated RAB2 interactor protein family contributes to murine male fertility to various extents by assuring correct morphogenesis of sperm heads
Wang H, Iida-Norita R, Mashiko D, Pham AH,#Miyata H , #Ikawa M. PLoS Genet.2024 Jun 27;20(6):e1011337. doi: 10.1371/journal.pgen.1011337. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38935810/
Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility
Nguyen TTT, #Tokuhiro K, Shimada K, Wang H, Mashiko D, Tonai S, Kiyozumi D, #Ikawa M. Front Cell Dev Biol. 2024 May 21:12:1411162. doi: 10.3389/fcell.2024.1411162. eCollection 2024. https://pubmed.ncbi.nlm.nih.gov/38835510/
Thirteen Ovary-Enriched Genes Are Individually Not Essential for Female Fertility in Mice
Pham AH, Emori C, Ishikawa-Yamauchi Y, Tokuhiro K, Kamoshita M, Fujihara Y, #Ikawa M. Cells. 2024 May 8;13(10):802. doi: 10.3390/cells13100802. https://pubmed.ncbi.nlm.nih.gov/38786026/
Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice
Suzuki A, #Yabuta N , Shimada K, Mashiko D, Tokuhiro K, Oyama Y, Miyata H, Garcia TX, Matzuk MM, #Ikawa M. J Reprod Immunol. 2024 Apr 29:163:104252. doi: 10.1016/j.jri.2024.104252. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38697008/
Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses #Metwally H, Elbrashy MM, Ozawa T, Okuyama K, White JT, Tulyeu J, Søndergaard JN, Wing JB, Muratsu A, Matsumoto H, Ikawa M, Kishi H, Taniuchi I, #Kishimoto T. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2402226121. doi: 10.1073/pnas.2402226121. Epub 2024 Apr 15. https://pubmed.ncbi.nlm.nih.gov/38621137/
Multiple genes in the Pate5-13 genomic region contribute to ADAM3 processing #Noda T, Shinohara H, Kobayashi S, Taira A , Oura S, Tahara D, Tokuyasu M, Araki K, #Ikawa M. Biol Reprod. 2024 Apr 11;110(4):750-760. doi: 10.1093/biolre/ioae008. https://pubmed.ncbi.nlm.nih.gov/38217862/
Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy
Liao Z, Tang S, Nozawa K, Shimada K, Ikawa M, #Monsivais D, #Matzuk M. Elife.2024 Mar 27:12:RP91434. doi: 10.7554/eLife.91434. https://pubmed.ncbi.nlm.nih.gov/38536963/
ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat
Nishio S, Emori C, Wiseman B, Fahrenkamp D, Dioguardi E, Zamora-Caballero S, Bokhove M, Han L, Stsiapanava A, Algarra B, Lu Y, Kodani M, Bainbridge R E, Komondor K M, Carlson A E, Landreh M, Sanctis D, Yasumasu S, Ikawa M, #Jovine L. Cell. 2024 Mar 14;187(6):1440-1459.e24. doi: 10.1016/j.cell.2024.02.013. https://pubmed.ncbi.nlm.nih.gov/38490181/
CUB domains are not required for OVCH2 function in sperm maturation in the mouse epididymis
Kent K , Nozawa K , Sutton C , Daniel F , Ikawa M , Garcia TX, #Matzuk MM. Andrology. 2024 Mar;12(3):682-697. doi: 10.1111/andr.13508. Epub 2023 Aug 8. https://pubmed.ncbi.nlm.nih.gov/37551853/
Tex46 knockout male mice are sterile secondary to sperm head malformations and failure to penetrate through the zona pellucida #Fujihara Y, Miyata H, Abbasi F, Larasati T, Nozawa K, Yu Z, Ikawa M, Matzuk MM. PNAS Nexus. 2024 Mar 12;3(3):pgae108. doi: 10.1093/pnasnexus/pgae108. eCollection 2024 Mar. https://pubmed.ncbi.nlm.nih.gov/38516277/
PABPN1L is required for maternal mRNA degradation after meiosis resumption
*Emori C, *Kodani M, Abbasi F, Mori M , #Ikawa M. J Reprod Dev. 2024 Feb 19;70(1):10-17. doi: 10.1262/jrd.2023-077. Epub 2023 Dec 7. https://pubmed.ncbi.nlm.nih.gov/38057116/
Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice
#Endo T, Kobayashi K, Matsumura T, Emori C, Ozawa M, Kawamoto S, Okuzaki D, Shimada K, Miyata H, Shimada K, Kodani M, Ishikawa-Yamauchi Y, Motooka D, Hara E, #Ikawa M. Commun Biol. 2024 Jan 4;7(1):16. doi: 10.1038/s42003-023-05685-2. https://pubmed.ncbi.nlm.nih.gov/38177279/