原著論文 Original Articles

2021年度

*equal contribution #corresponding author

  1. Ali El Hussien M, Tsai CY, #Satouh Y, Motooka D, Okuzaki D, Ikawa M, #Kikutani H, #Sakakibara S.
    Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice.
    Int Immunol. 2021 Dec 1;dxab111. doi: 10.1093/intimm/dxab111. Online ahead of print.
    https://pubmed.ncbi.nlm.nih.gov/34865040/
     
  2. *Morohoshi A, *Miyata H, Oyama Y, Oura S, Noda T, #Ikawa M.
    FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility in mice.
    Development. 2021 Nov 1;148(21):dev199644. doi: 10.1242/dev.199644. Epub 2021 Oct 29.
    https://pubmed.ncbi.nlm.nih.gov/34714330/
     
  3. Fukui Y, #Hirota Y, Saito-Fujita T, Aikawa S, Hiraoka T, Kaku T, Hirata T, Akaeda S, Matsuo M, Shimizu-Hirota R, Takeda N, Ikawa M, Osuga Y.
    Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment.
    Endocrinology. 2021 Nov 1;162(11):bqab169. doi: 10.1210/endocr/bqab169.
    https://pubmed.ncbi.nlm.nih.gov/34402888/
     
  4. #Kojima-Kita K, Kuramochi-Miyagawa S, Nakayama M, Miyata H, Jacobsen SE, Ikawa M, Koseki H, #Nakano T.
    MORC3, a novel MIWI2 association partner, as an epigenetic regulator of piRNA dependent transposon silencing in male germ cells.
    Sci Rep. 2021 Oct 14;11(1):20472. doi: 10.1038/s41598-021-98940-7.
    https://pubmed.ncbi.nlm.nih.gov/34650118/
     
  5. *Zhang X, *Sun J, *Lu Y, *Zhang J, Shimada K, Noda T, Zhao S, Koyano T, Matsuyama M, Zhou S, Wu J, #Ikawa M, #Liu M.
    LRRC23 is a conserved component of the radial spoke that is necessary for sperm motility and male fertility in mice.
    J Cell Sci. 2021 Sep 29:jcs.259381. doi: 10.1242/jcs.259381. Epub 2021 Oct 21.
    https://pubmed.ncbi.nlm.nih.gov/34585727/
     
  6. *Fujihara Y, *Herberg S, Blaha A, Panser K, Kobayashi K, Larasati T, Novatchkova M, Theussl HC, Olszanska O, #Ikawa M, #Pauli A.
    The conserved fertility factor SPACA4/Bouncer has divergent modes of action in vertebrate fertilization.
    Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2108777118. doi: 10.1073/pnas.2108777118.
    https://pubmed.ncbi.nlm.nih.gov/34556579/
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  7. *Segawa K, *Kikuchi A, Noji T, Sugiura Y, Hiraga K, Suzuki C, Haginoya K, Kobayashi Y, Matsunaga M, Ochiai Y, Yamada K, Nishimura T, Iwasawa S, Shoji W, Sugihara F, Nishino K, Kosako H, Ikawa M, Uchiyama Y, Suematsu M, Ishikita H, Kure S, Nagata S.
    A sublethal ATP11A mutation associated with neurological deterioration causes aberrant phosphatidylcholine flipping in plasma membranes.
    J Clin Invest. 2021 Sep 15;131(18):e148005. doi: 10.1172/JCI148005.
    https://pubmed.ncbi.nlm.nih.gov/34403372/
     
  8. #Castaneda JM, Shimada K, Satouh Y, Yu Z, Ikawa M, Matzuk MM.
    FAM209 associates with DPY19L2 and is required for sperm acrosome biogenesis and fertility in mice.
    J Cell Sci. 2021 Nov 1;134(21):jcs259206. doi: 10.1242/jcs.259206. Epub 2021 Nov 1.
    https://pubmed.ncbi.nlm.nih.gov/34471926/
     
  9. Miyata H,  Oura S,  Morohoshi A,  Shimada K, Mashiko D, Oyama Y, Kaneda Y, Matsumura T, Abbasi F, #Ikawa M.
    SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.
    PNAS. August 31, 2021 118 (35) e2106673118; https://doi.org/10.1073/pnas.2106673118
    https://pubmed.ncbi.nlm.nih.gov/34446558/
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  10. #Mori M, Yao T, Mishina T, Endoh H, Tanaka M, Yonezawa N, Shimamoto Y, Yonemura S, Yamagata K, Kitajima TS, #Ikawa M.
    RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization.
    J Cell Biol. 2021 Oct 4;220(10):e202012001. doi: 10.1083/jcb.202012001. Epub 2021 Aug 23.
    https://pubmed.ncbi.nlm.nih.gov/34424312/
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  11. Yamamuro T, #Nakamura S, Yamano Y, Endo T, Yanagawa K, Tokumura A, Matsumura T, Kobayashi K, Mori H, Enokidani Y, Yoshida G, Imoto H, Kawabata T, Hamasaki M, Kuma A, Kuribayashi S, Takezawa K, Okada Y, Ozawa M, Fukuhara S, Shinohara T, Ikawa M, #Yoshimori T.
    Rubicon prevents autophagic degradation of GATA4 to promote Sertoli cell function.
    PLoS Genet. 2021 Aug 5;17(8):e1009688. doi: 10.1371/journal.pgen.1009688. eCollection 2021 Aug.
    https://pubmed.ncbi.nlm.nih.gov/34351902/
     
  12. #Yoshida K, Fujita SI, Isotani A, Kudo T, Takahashi S, Ikawa M, Shiba D, Shirakawa M, Muratani M, Ishii S.
    Intergenerational effect of short-term spaceflight in mice.
    iScience. 2021 Jun 25;24(7):102773. doi: 10.1016/j.isci.2021.102773. eCollection 2021 Jul 23.
    https://pubmed.ncbi.nlm.nih.gov/34278272/
     
  13. Oyama Y, #Miyata H, Shimada K, Fujihara Y, Tokuhiro K, Garcia TX, Matzuk MM, #Ikawa M.
    CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice.
    Asian J Androl. 2022 May-Jun;24(3):266-272. doi: 10.4103/aja.aja_63_21.
    https://pubmed.ncbi.nlm.nih.gov/34290169/
     
  14. Oura S, Noda T, Morimura N, Hitoshi S, Nishimasu H, Nagai Y, Nureki O, #Ikawa M.
    Precise CAG repeat contraction in a Huntington’s Disease mouse model is enabled by gene editing with SpCas9-NG.
    Commun Biol. 2021 Jun 23;4(1):771. doi: 10.1038/s42003-021-02304-w.
    https://pubmed.ncbi.nlm.nih.gov/34163001/
     
  15. #Monsivais D, Nagashima T, Prunskaite-Hyyryläinen R, Nozawa K, Shimada K, Tang S, Hamor C, Agno JE, Chen F, Masand RP, Young SL, Creighton CJ, DeMayo FJ, Ikawa M, Lee SJ, #Matzuk MM.
    Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis.
    Nat Commun. 2021 Jun 7;12(1):3386. doi: 10.1038/s41467-021-23571-5.
    https://pubmed.ncbi.nlm.nih.gov/34099644/
     
  16. Shibata T, Ikawa M, Sakasai R, Ishigaki Y, Kiyokawa E, Iwabuchi K, Singh DP, Sasaki H, #Kubo E.
    Lens-specific conditional knockout of tropomyosin 1 gene in mice causes abnormal fiber differentiation and lens opacity.
    Mech Ageing Dev. 2021 Jun;196:111492. doi: 10.1016/j.mad.2021.111492. Epub 2021 Apr 15.
    https://pubmed.ncbi.nlm.nih.gov/33862037/
     
  17. Oura S, Koyano T, Kodera C, Horisawa-Takada Y, Matsuyama M, Ishiguro KI, #Ikawa M.
    KCTD19 and its associated protein ZFP541 are independently essential for meiosis in male mice.
    PLoS Genet. 2021 May 7;17(5):e1009412. doi: 10.1371/journal.pgen.1009412. eCollection 2021 May.
    https://pubmed.ncbi.nlm.nih.gov/33961623/
     
  18. Kishimoto Y, Nishiura I, Hirata W, Yuri S, Yamamoto N, Ikawa M, #Isotani A.
    A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models.
    Sci Rep. 2021 Apr 15;11(1):8297. doi: 10.1038/s41598-021-87751-5.
    https://pubmed.ncbi.nlm.nih.gov/33859300/
     
  19. Matsuo T, Isosaka T, Hayashi Y, Tang L, Doi A, Yasuda A, Hayashi M, Lee CY, Cao L, Kutsuna N, Matsunaga S, Matsuda T, Yao I, Setou M, Kanagawa D, Higasa K, Ikawa M, #Liu Q, #Kobayakawa R, #Kobayakawa K.
    Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation.
    Nat Commun. 2021 Apr 6;12(1):2074. doi: 10.1038/s41467-021-22205-0.
    https://pubmed.ncbi.nlm.nih.gov/33824316/
     
  20. Qu Y, Chen Q, Guo S, Ma C, Lu Y, Shi J, Liu S, Zhou T, Noda T, Qian J, Zhang L, Zhu X, Lei X, Cao Y, Li W, Li W, Plachta N, Matzuk MM, Ikawa M, #Duan E, #Zhang Y, #Wang H.
    Cooperation-based sperm clusters mediate sperm oviduct entry and fertilization.
    Protein Cell. 2021 Oct;12(10):810-817. doi: 10.1007/s13238-021-00825-y. Epub 2021 Mar 1.
    https://pubmed.ncbi.nlm.nih.gov/33649997/
     
  21. Shimada K, Park S, Miyata H, Yu Z, Morohoshi A, Oura S, #Matzuk MM, #Ikawa M.
    ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility.
    Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018355118.
    https://pubmed.ncbi.nlm.nih.gov/33536340/
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  22. *#Fukuda E, *Tanaka H, Yamaguchi K, Takasaka M, Kawamura Y, Okuda H, Isotani A, Ikawa M, Shapiro VS, Tsuchida J, Okada Y, Tsujimura A, Miyagawa Y, Fukuhara S, Kawakami Y, Wada M, Nishimune Y, Goshima N.
    Identification and characterization of the antigen recognized by the germ cell mAb TRA98 using a human comprehensive wet protein array.
    Genes Cells. 2021 Mar;26(3):180-189. doi: 10.1111/gtc.12832.
    https://pubmed.ncbi.nlm.nih.gov/33527666/
     
  23. Zhou Z, Okamoto K, Onodera J, Hiragi T, Andoh M, Ikawa M, Tanaka KF, Ikegaya Y, Koyama R.
    Astrocytic cAMP modulates memory via synaptic plasticity.
    Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e2016584118. 
    https://pubmed.ncbi.nlm.nih.gov/33452135/
     
  24. #Kim CR, Noda T, Okada Y, #Ikawa M, #Baek SH.
    Protocol for isolation of spermatids from mouse testes.
    STAR Protoc. 2021 Jan 8;2(1):100254. 
    https://pubmed.ncbi.nlm.nih.gov/33490974/