原著論文 Original Articles

2020年

* equal contribution # corresponding author

  1. #Miyamoto Y, Sasaki M, Miyata H, Monobe Y, Nagai M, Otani M, Whiley PAF, Morohoshi A, Oki S, Matsuda J, Akagi KI, Adachi J, Okabe M, Ikawa M, Yoneda Y, Loveland KL, #Oka M.
    Genetic loss of importin α4 causes abnormal sperm morphology and impacts on male fertility in mouse
    FASEB J. 2020 Dec;34(12):16224-16242.
    https://pubmed.ncbi.nlm.nih.gov/33058343/
     
  2. *Akıncılar SC, *Wu L, Ng QF, Chua JYH, Unal B, Noda T, Chor WHJ, Ikawa M, #Tergaonkar V.
    NAIL: an evolutionarily conserved lncRNA essential for licensing coordinated activation of p38 and NFκB in colitis
    Gut. 2020 Nov 25;gutjnl-2020-322980. doi: 10.1136/gutjnl-2020-322980. Online ahead of print.
    https://pubmed.ncbi.nlm.nih.gov/33239342/
     
  3. #Miyata H, Morohoshi A, #Ikawa M.
    Analysis of the sperm flagellar axoneme using gene-modified mice.
    Exp Anim.  2020 Nov 12;69(4):374-381.
    https://pubmed.ncbi.nlm.nih.gov/32554934/
     
  4. #Miyata H, Abbasi F, Visconti PE, #Ikawa M.
    CRISPR/CAS9-mediated amino acid substitution reveals phosphorylation residues of RSPH6A are not essential for male fertility in mice
    Biol Reprod. 2020 Oct 29;103(5):912-914. 
    https://pubmed.ncbi.nlm.nih.gov/32901808/
     
  5. Lee GH, Fujita M, Nakanishi H, Miyata H, Ikawa M, Maeda Y, Murakami Y, #Kinoshita T.
    PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins
    J Biol Chem.2020 Oct 16;295(42):14501-14509. 
    https://pubmed.ncbi.nlm.nih.gov/32816994/
     
  6. Senoo M, Hozoji H, Ishikawa-Yamauchi Y, Takijiri T, Ohta S, Ukai T, Kabata M, Yamamoto T, Yamada Y, #Ikawa M, #Ozawa M.
    RNA-binding Protein Ptbp1 Regulates Alternative Splicing and Transcriptome in Spermatogonia and Maintains Spermatogenesis in Concert With Nanos3.
    J Reprod Dev.  2020 Oct 13;66(5):459-467. 
    https://pubmed.ncbi.nlm.nih.gov/32624547/
     
  7. #Bai J, Kondo R, Mayasari NI, Shigeoka T, Isotani A, Ikawa M, Sashida G, Kawaichi M, #Ishida Y.
    Diphtheria Toxin-Mediated Transposon-Driven Poly (A)-trapping Efficiently Disrupts Transcriptionally Silent Genes in Embryonic Stem Cells.
    Genesis. 2020 Sep;58(9):e23386.
    https://pubmed.ncbi.nlm.nih.gov/32645254/
     
  8. Kim H, Takegahara N, Walsh MC, Ueda J, Fujihara Y, Ikawa M, #Choi Y.
    Protocadherin-7 Contributes to Maintenance of Bone Homeostasis Through Regulation of Osteoclast Multinucleation.
    BMB Rep. 2020 Sep;53(9):472-477. 
    https://pubmed.ncbi.nlm.nih.gov/32635982/
     
  9. Robertson MJ, Kent K, Tharp N, Nozawa K, Dean L, Mathew M, Grimm SL, Yu Z, Légaré C, Fujihara Y, Ikawa M, Sullivan R, #Coarfa C, Matzuk MM, #Garcia TX.
    Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.
    BMC Biol. 2020 Aug 19;18(1):103.
    https://pubmed.ncbi.nlm.nih.gov/32814578/
     
  10. *Liu C, *Miyata H, *Gao Y, *Sha Y, *Tang S, *Xu Z, Whitfield M, Patrat C, Wu H, Dulioust E, Tian S, Shimada K, Cong J, Noda T, Li H, Morohoshi A, Cazin C, Kherraf ZE, Arnoult C, Jin L, He X, Ray PF, Cao Y, Touré A, #Zhang F, #Ikawa M. *:equal contribution.
    Bi-allelic DNAH8 Variants Lead to Multiple Morphological Abnormalities of the Sperm Flagella and Primary Male Infertility.
    Am J Hum Genet. 2020 Aug 6;107(2):330-341. Epub 2020 Jul 2.
    https://pubmed.ncbi.nlm.nih.gov/32619401/
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  11. Devlin DJ, Nozawa K, Ikawa M, #Matzuk MM. 
    Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in mice.
    Biol Reprod. 2020 Aug 4;103(2):205-222. 
    https://pubmed.ncbi.nlm.nih.gov/32588889/
     
  12. *Park S, *Shimada K, Fujihara Y, Xu Z, Shimada K, Larasati T, Pratiwi P, Matzuk RM, Devlin DJ, Yu Z, Garcia TX, #Matzuk MM, #Ikawa M. *:equal contribution.
    CRISPR/Cas9-mediated genome-edited mice reveal 10 testis-enriched genes are dispensable for male fecundity.
    Biol Reprod. 2020 Aug 4;103(2):195-204. 
    https://pubmed.ncbi.nlm.nih.gov/32561905/
     
  13. *Sun J, *Lu Y, Nozawa K, Xu Z, Morohoshi A, Castaneda JM, Noda T, Miyata H, Abbasi F, Shawki HH, Takahashi S, Devlin DJ, Yu Z, Matzuk RM, Garcia TX, #Martin MM, #Ikawa M. *:equal contribution.
    CRISPR/Cas9-based genome editing in mice uncovers 13 testis- or epididymis-enriched genes individually dispensable for male reproduction.
    Biol Reprod. 2020 Aug 4;103(2):183-194. 
    https://pubmed.ncbi.nlm.nih.gov/32588039/
     
  14. *Xu Z, *Miyata H, Kaneda Y, Castaneda JM, Lu Y, Morohoshi A, Yu Z, Matzuk MM, #Ikawa M.
    CIB4 Is Essential for the Haploid Phase of Spermatogenesis in Mice.
    Biol Reprod. 2020 Aug 4;103(2):235-243. 
    https://pubmed.ncbi.nlm.nih.gov/32430498/
     
  15. *Larasati T, *Noda T, Fujihara Y, Shimada K, Tobita T, Yu Z, #Matzuk MM, #Ikawa M. *:equal contribution
    Tmprss12 is required for sperm motility and uterotubal junction migration in mice.
    Biol Reprod. 2020 Aug 4;103(2):254-263.
    https://pubmed.ncbi.nlm.nih.gov/32529245/
     
  16. Nozawa K, Zhang Q, Miyata H, Devlin DJ, Yu Z, Oura S, Koyano T, Matsuyama M, #Ikawa M, #Matzuk MM.
    Knockout of serine-rich single-pass membrane protein 1 (Ssmem1) causes globozoospermia and sterility in male mice.
    Biol Reprod. 2020 Aug 4;103(2):244-253. 
    https://pubmed.ncbi.nlm.nih.gov/32301969/
     
  17. *Kobayashi K, *Endo T, Matsumura T, Lu Y, Yu Z, #Matzuk MM, #Ikawa M.*:equal contribution
    Prss55 but Not Prss51 Is Required for Male Fertility in Mice.
    Biol Reprod. 2020 Aug 4;103(2):223-234. 
    https://pubmed.ncbi.nlm.nih.gov/32301961/
     
  18. *Kim CR,*Noda T, Kim H, Kim G, Park S, Na Y, Oura S, Shimada K, Bang I, Ahn JY, Kim YR, Oh SK, Choi HJ, Kim JS, Jung I, Lee H, Okada Y, #Ikawa M, #Baek SH. *:equal contribution.
    PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.
    Cell Rep. 2020 Jul 28;32(4):107950. 
    https://pubmed.ncbi.nlm.nih.gov/32726616/
     
  19. #Patricia V Turner, Debra L Hickman, Judith van Luijk, Merel Ritskes-Hoitinga, Jan M Sargeant , T Miki Kurosawa, Takashi Agui, Vera Baumans, Woo Sung Choi, Yang-Kyu Choi , Paul A Flecknell, Byeong H Lee, Pedro J Otaegui, Kathleen R Pritchett-Corning, Keisuke Shimada
    Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice and Rats: A Systematic Review
    Front Vet Sci. 2020 Jul 22;7:411.
    https://pubmed.ncbi.nlm.nih.gov/32793645/
     
  20. Kiyozumi D, Noda T, Yamaguchi R, Tobita T, Matsumura T, Shimada K, Kodani M, Kohda T, Fujihara Y, Ozawa M, Yu Z, Miklossy G, Bohren MK, Horie M, Okabe M, #Matzuk MM, #Ikawa M.
    NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility.
    Science. 2020 Jun 5;368(6495):1132-1135. doi: 10.1126/science.aay5134.
    https://pubmed.ncbi.nlm.nih.gov/32499443/
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    Click for the Abstract  and Full text  provided by AAAS/Science.
     
  21. #*Kojima M, Otabi H, Kumanogoh H, Toyoda A, Ikawa M, Okabe M, #*Mizui T. *:equal contribution.
    Reduction in BDNF From Inefficient Precursor Conversion Influences Nest Building and Promotes Depressive-Like Behavior in Mice.
    Int J Mol Sci. 2020 Jun 1;21(11):E3984. 
    https://pubmed.ncbi.nlm.nih.gov/32492978/
     
  22. *Noda T, *Lu Y, Fujihara Y, Oura S, Koyano T, Kobayashi S, Matzuk MM,  #Ikawa M.*:equal contribution
    Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice.
    Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502. doi: 10.1073/pnas.1922650117. Epub 2020 May 11.
    https://pubmed.ncbi.nlm.nih.gov/32393636/
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  23. Fujihara Y, Lu Y, Noda T, Oji A, Larasati T, Kojima-Kita K, Yu Z, Matzuk RM, #Matzuk MM, #Ikawa M. 
    Spermatozoa Lacking Fertilization Influencing Membrane Protein (FIMP) Fail to Fuse With Oocytes in Mice.
    PNAS. 2020 Apr 28;117(17):9393-9400.
    https://pubmed.ncbi.nlm.nih.gov/32295885/
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  24. #Castaneda JM, Miyata H, Archambeault DR, Satouh Y, Yu Z, Ikawa M, Matzuk MM.
    Mouse T-complex protein 11 is important for progressive motility in sperm.
    Biol Reprod. 2020 Apr 15;102(4):852-862. 
    https://www.ncbi.nlm.nih.gov/pubmed/31837139/
     
  25. Oji A, Isotani A, Fujihara Y, Castaneda JM, Oura S, #Ikawa M.
    TESMIN, METALLOTHIONEIN-LIKE 5, is required for spermatogenesis in mice.
    Biol Reprod. 2020 Apr 15;102(4):975-983. doi: 10.1093/biolre/ioaa002.
    https://www.ncbi.nlm.nih.gov/pubmed/31916570 
     
  26. #Miyata H, Shimada K, Morohoshi A, Oura S, Matsumura T, Xu Z, Oyama Y, #Ikawa M.
    Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa.
    FASEB J. 2020 Apr;34(4):5389-5400.
    https://www.ncbi.nlm.nih.gov/pubmed/32072696/ 
     
  27. *Umeda R, *Satouh Y, Takemoto M, Nakada-Nakura Y, Liu K, Yokoyama T, Shirouzu M, Iwata S, Nomura N, Sato K, Ikawa M, #Nishizawa T, #Nureki O. *:equal contribution
    Structural Insights Into Tetraspanin CD9 Function.
    Nat Commun. 2020 Mar 30;11(1):1606.
    https://pubmed.ncbi.nlm.nih.gov/32231207/ 
     
  28. *Abbasi F, *Kodani M, Emori C, Kiyozumi D, Mori M, Fujihara Y, #Ikawa M. *:equal contribution
    CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice
    Cells. 2020;9(4):E821. Published 2020 Mar 28.
    https://pubmed.ncbi.nlm.nih.gov/32231122/
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  29. Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, #Ogita H.
    Identification of Transmembrane Protein 168 Mutation in Familial Brugada Syndrome.
    FASEB J. 2020 May;34(5):6399-6417.Epub 2020 Mar 16.
    https://pubmed.ncbi.nlm.nih.gov/32175648/ 
    icon-star.png滋賀医大プレスリリース
     
  30. Tsumagari R, Kakizawa S, Kikunaga S, Fujihara Y, Ueda S, Yamanoue M, Saito N, Ikawa M, #Shirai Y.
    DGKγ knockout mice show impairments in cerebellar motor coordination, LTD and the dendritic development of Purkinje cells through the activation of PKCγ.
    eNeuro. 2020 Mar 4;7(2):ENEURO.0319-19.2020. doi: 10.1523/ENEURO.0319-19.2020. Print Mar/Apr 2020.
    https://www.ncbi.nlm.nih.gov/pubmed/32033984  
     
  31. Holcomb RJ, Oura S, Nozawa K, Kent K, Yu Z, Robertson MJ, Coarfa C, Matzuk MM, Ikawa M, #Garcia TX.
    The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility.
    Biol Reprod. 2020 Feb 12;102(1):84-91.
    https://www.ncbi.nlm.nih.gov/pubmed/31403672​​​​​​ 
     
  32. *Kondo H, *Matsumura T, Kaneko M, Inoue K, Kosako H, Ikawa M, Takahama Y, #Ohigashi I. 
    *:equal contribution
    PITHD1 is a proteasome-interacting protein essential for male fertilization.
    J Biol Chem.  2020 Feb 7;295 (6):1658-1672.
    https://www.ncbi.nlm.nih.gov/pubmed/31915251  
     
  33. *Kim H, Takegahara N, Walsh MC, Middleton SA, Yu J, Shirakawa J, Ueda J, Fujihara Y, Ikawa M, Ishii M, Kim J, #Choi Y.  *:equal contribution
    IgSF11 regulates osteoclast differentiation through association with the scaffold protein PSD-95.
    Bone Res. 2020 Feb 10;8:5.
    https://www.ncbi.nlm.nih.gov/pubmed/32047704  
     
  34. #Kiyozumi D, Mori M, Kodani M, #Ikawa M.
    Genetic mutation of Frem3 does not cause Fraser syndrome in mice.
    Exp Anim. 2020 Jan 29;69(1):104-109.
    https://www.ncbi.nlm.nih.gov/pubmed/31554749 ​​​​​​
     
  35. Morohoshi A, Miyata H, Shimada K, Nozawa K, Matsumura T, Yanase R, Shiba K, Inaba K, #Ikawa M.
    Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.
    PLoS Genet. 2020 Jan 21;16(1):e1008585. doi: 10.1371/journal.pgen.1008585. eCollection 2020 Jan.
    https://www.ncbi.nlm.nih.gov/pubmed/319618​​​​​​​