Emori C, Kodani M, Abbasi F, Mori M, #Ikawa M
PABPN1L is required for maternal mRNA degradation after meiosis resumption J Reprod Dev. 2023 Dec 7. doi: 10.1262/jrd.2023-077. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38057116/
#Ogawa Y, #Lu Y, Kiyozumi D, Chang H, Ikawa M
CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice Andrology. 2023 Dec 12. doi: 10.1111/andr.13564. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/38084666/
#Ozawa M, Mori H, Endo T, Ishikawa-Yamauchi Y, Motooka D, Emori C, #Ikawa M.
Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice iScience. 2023 Nov 13;26(12):108456. doi: 10.1016/j.isci.2023.108456. eCollection 2023 Dec 15. https://pubmed.ncbi.nlm.nih.gov/38077127/
#Shimada K, #Ikawa M
CCDC183 is essential for cytoplasmic invagination around the flagellum during spermiogenesis and male fertility Development. 2023 Nov 1;150(21):dev201724. doi: 10.1242/dev.201724. Epub 2023 Oct 30. https://pubmed.ncbi.nlm.nih.gov/37882665/
#Kiyozumi D, Ikawa M.
ADGRG2 is dispensable for lumicrine signalling regulating epididymal initial segment differentiation and gene expression. Biology of Reproduction. 2023 Oct 13;109(4):474-481. doi: 10.1093/biolre/ioad087. https://pubmed.ncbi.nlm.nih.gov/37531264/
#Shinzawa K, Matsumoto S, Sada R, Harada A, Saitoh K, Kato K, Ikeda S, Hirayama A, Yokoi K, Tanemura A, Nimura K, Ikawa M, Soga T, #Kikuchi A.
GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation Oncogene. 2023 Oct;42(42):3142-3156. doi: 10.1038/s41388-023-02803-6. Epub 2023 Sep 1. https://pubmed.ncbi.nlm.nih.gov/37658191/
Huang X, Miyata H, Wang H, Mori G, Iida-Norita R, Ikawa M, Percudani R, #Chung JJ.
A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking
Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2304409120. doi: 10.1073/pnas.2304409120. Epub 2023 Sep 19. https://pubmed.ncbi.nlm.nih.gov/37725640/
Ihashi S, Hamanaka M, Kaji M, Mori R, Nishizaki S, Mori M, Imasato Y, Inoue K, Matoba S, Ogonuki N, Takasu A, Nakamura M, Matsumoto K, Anzai M, Ogura A, Ikawa M, #Miyamoto K
Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos Life Sci Alliance. 2023 Aug 28;6(11):e202302296. doi: 10.26508/lsa.202302296. Print 2023 Nov. https://pubmed.ncbi.nlm.nih.gov/37640449/
Nozawa K, Liao Z, Satouh Y, Geng T, Ikawa M, #Monsivais D, #Matzuk MM
Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in mice PLoS One. 2023 Aug 1;18(8):e0289083. doi: 10.1371/journal.pone.0289083. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37527245/
Sutton C, Nozawa K, Kent K, Saltzman A, Leng M, Nagarajan S, Malovannaya A, Ikawa M, Garcia TX & #Matzuk MM.
Molecular dissection and testing of PRSS37 function through LC-MS/MS and the generation of a PRSS37 humanized mouse model Sci Rep. 2023 Jul 14;13(1):11374. doi: 10.1038/s41598-023-37700-1. https://pubmed.ncbi.nlm.nih.gov/37452050/
#Funaya S, Wang Y, Suzuki MG, Ikawa M, #Aoki F
Involvement of linker histone variant H1a in the regulation of early preimplantation development in mice J Reprod Dev. 2023 Jun 6;69(3):178-182. doi: 10.1262/jrd.2023-013. Epub 2023 Apr 17. https://pubmed.ncbi.nlm.nih.gov/37062716/
#Shimada K, Lu Y, #Ikawa M.
Disruption of testis-enriched cytochrome c oxidase subunit COX6B2 but not COX8C leads to subfertility. Exp Anim.2024 Feb 14;73(1):1-10. doi: 10.1538/expanim.23-0055. Epub 2023 Jul 10. https://pubmed.ncbi.nlm.nih.gov/37423748/
#Kiyozumi D, Shimada K, Chalick M, Emori C, Kodani M, Oura S, Noda T, Endo T, Matzuk MM, #Wreschner DH, #Ikawa M.
A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility Nat Commun. 2023 Apr 24;14(1):2354. doi: 10.1038/s41467-023-37984-x. https://pubmed.ncbi.nlm.nih.gov/37095084/
Shirai T, Nakai A, Ando E, Fujimoto J, Leach S, Arimori T, Higo D, van Eerden FJ, Tulyeu J, Liu YC, Okuzaki D, Murayama MA, Miyata H, Nunomura K, Lin B, Tani A, Kumanogoh A, Ikawa M, Wing JB, Standley DM, Takagi J, #Suzuki K.
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Sci Immunol. 2023 Mar 31;8(81):eadc9324. doi: 10.1126/sciimmunol.adc9324. Epub 2023 Mar 31. https://pubmed.ncbi.nlm.nih.gov/37000855/
Miyake T, Inoue Y, Shao X, Seta T, Aoki Y, Nguyen Pham KT, Shichino Y, Sasaki J, Sasaki T, Ikawa M, Yamaguchi Y, Okamura H, Iwasaki S, #Doi M.
Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm. Cell Rep. 2023 Mar 28;42(3):112157. doi: 10.1016/j.celrep.2023.112157. Epub 2023 Mar 6. https://pubmed.ncbi.nlm.nih.gov/36882059/
Huang X, Miyata H, Wang H, Mori G, Iida-Norita R, Ikawa M, Percudani R, #Chung JJ.
A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking. bioRxiv [Preprint]. 2023 Mar 17:2023.03.17.532952. doi: 10.1101/2023.03.17.532952. https://pubmed.ncbi.nlm.nih.gov/36993167/
#Shimada K, Park S, Oura S, Noda T, Morohoshi A, #Matzuk MM, #Ikawa M.
TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2221762120. doi: 10.1073/pnas.2221762120. Epub 2023 Mar 7. https://pubmed.ncbi.nlm.nih.gov/36881620/
Kuribayashi S, #Fukuhara S, Tsujimura G, Imanaka T, Okada K, Ueda N, Takezawa K, Kiuchi H, Saito S, Takahashi Y, Kioka H, Oura S, Shimada K, Ikawa M, Nonomura N.
Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity. Reprod Med Biol. 2023 Feb 23;22(1):e12507. doi: 10.1002/rmb2.12507. https://pubmed.ncbi.nlm.nih.gov/36845001/
Lu Y, Shimada K, Tang S, Zhang J, Ogawa Y, Noda T, Shibuya H, #Ikawa M.
1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2207263120. doi: 10.1073/pnas.2207263120. Epub 2023 Feb 14. https://pubmed.ncbi.nlm.nih.gov/36787362/
#Ozawa M, Emori C & #Ikawa M
Gene Targeting in Mouse Embryonic Stem Cells via CRISPR/Cas9 Ribonucleoprotein (RNP)-Mediated Genome Editing Methods Mol Biol. 2023:2637:87-97. doi: 10.1007/978-1-0716-3016-7_7. https://pubmed.ncbi.nlm.nih.gov/36773140/
Lu Y, Nagamori I, Kobayashi H, Kojima-Kita K, Shirane K, Chang HY, Nishimura T, Koyano T, Yu Z, Castañeda JM, Matsuyama M, #Kuramochi-Miyagawa S, #Matzuk MM, #Ikawa M.
ADAD2 functions in spermiogenesis and piRNA biogenesis in mice. Andrology. 2023 Jan 25. doi: 10.1111/andr.13400. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36698249/
*Morohoshi A, #*Miyata H, Tokuhiro K, Iida-Norita R, Noda T, Fujihara Y, #Ikawa M.
Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility. Sci Adv. 2023 Jan 25;9(4):eade7607. doi: 10.1126/sciadv.ade7607. Epub 2023 Jan 25. https://pubmed.ncbi.nlm.nih.gov/36696506/
Morita M, Yoneda A, Tokunoh N, Masaki T, Shirakura K, Kinoshita M, Hashimoto R, Shigesada N, Takahashi J, Tachibana M, Tanaka S, Obana M, Hino N, Ikawa M, Tsujikawa K, Ono C, Matsuura Y, Kidoya H, Takakura N, Kubota Y, Doi T, Takayama K, Yoshioka Y, Fujio Y, #Okada Y.
Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models. Proc Natl Acad Sci U S A. 2023 Jan 17;120(3):e2213317120. doi: 10.1073/pnas.2213317120. Epub 2023 Jan 12. https://pubmed.ncbi.nlm.nih.gov/36634143/
Kaneda Y, #Miyata H, Shimada K, Oura S, #Ikawa M.
Testis-specific proteins, TSNAXIP1 and 1700010I14RIK, are important for sperm motility and male fertility in mice. Andrology. 2023 Jan 4. doi: 10.1111/andr.13378. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36598146/