原著論文 Original Articles

2019年

  1. Nakashima A, Cheng SB, Ikawa M, Yoshimori T, Huber WJ, Menon R, Huang Z, Fierce J, Padbury JF, Sadovsky Y, Saito S, *Sharma S.
    Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
    Autophagy. 2019 Dec 20. Epub ahead of print.
    https://www.ncbi.nlm.nih.gov/pubmed/31856641  
     
  2. Khattar E, Maung KZY, Chew CL, Ghosh A, Mok MMH, Lee P, Zhang J, Chor WHJ, Cildir G, Wang CQ, Mohd-Ismail NK, Chin DWL, Lee SC, Yang H, Shin YJ, Nam DH, Chen L, Kumar AP, Deng LW, Ikawa M, Gunaratne J, Osato M, *Tergaonkar V.
    Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy.
    Nat Commun. 2019 Dec 13;10(1):5349.
    https://www.ncbi.nlm.nih.gov/pubmed/31836706  
     
  3. Kawai T, Miyata H, Nakanishi H, Sakata S, Morioka S, Sasaki J, Watanabe M, Sakimura K, Fujimoto T, Sasaki T, Ikawa M, *Okamura Y.
    Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility.
    PNAS. 2019 Dec 17;116(51):26020-26028. 
    https://www.ncbi.nlm.nih.gov/pubmed/31776261
     
  4. *Serizawa T, Isotani A, Matsumura T, Nakanishi K, Nonaka S, Shibata S, Ikawa M, *Okano H.
    Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers.
    Development 2019 Nov 4;146(21). pii: dev174938.
    https://www.ncbi.nlm.nih.gov/pubmed/31597657  
     
  5. §Matsumura T, §Noda T, Muratani M, Okada R, Yamane M, Isotani A, Kudo T, Takahashi S, *Ikawa M.
    §: equal contribution
    Male mice, caged in the International Space Station for 35 days, sire healthy offspring.
    Sci Rep. 2019 Sep 24;9(1):13733.
    https://www.ncbi.nlm.nih.gov/pubmed/31551430
    微研プレスリリース

  6. §Fujihara Y, §Noda T, §Kobayashi K, Oji A, Kobayashi S, Matsumura T, Larasati T, Oura S, Kojima-Kita K, Yu Z, *Matzuk MM, *Ikawa M.
    §: equal contribution
    Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice.
    PNAS 2019 Sep 10;116(37):18498-18506.
    https://www.ncbi.nlm.nih.gov/pubmed/31455729
    微研プレスリリース  
     
  7. Hayashi M, *Machida T, Ishida Y, Ogata Y, Omori T, Takasumi M, Endo Y, Suzuki T, Sekimata M, Homma Y, Ikawa M, Ohira H, Fujita T, Sekine H.
    Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway.
    J Immunol. 2019 Sep 15;203(6):1411-1416.
    https://www.ncbi.nlm.nih.gov/pubmed/31399515
     
  8. Sasaki K, Shiba K, Nakamura A, Kawano N, Satouh Y, Yamaguchi H, Morikawa M, Shibata D, Yanase R, Jokura K, Nomura M, Miyado M, Takada S, Ueno H, Nonaka S, Baba T, Ikawa M, Kikkawa M, Miyado K, *Inaba K.
    Calaxin is required for cilia-driven determination of vertebrate laterality.
    Commun Biol. 2019 Jun 20;2:226.
    https://www.ncbi.nlm.nih.gov/pubmed/31240264
    微研プレスリリース  
     
  9. Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, *Ikawa M.
    CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice.
    Biol Reprod. 2019 Aug 1;101(2):501-511.
    https://www.ncbi.nlm.nih.gov/pubmed/31201419
     
  10. Shiromoto Y, *Kuramochi-Miyagawa S, Nagamori I, Chuma S, Arakawa T, Nishimura T, Hasuwa H, Tachibana T, Ikawa M, *Nakano T.
    GPAT2 is required for piRNA biogenesis, transposon silencing, and maintenance of spermatogonia in mice.
    Biol Reprod. 2019 Apr 5. pii: ioz056.
    https://www.ncbi.nlm.nih.gov/pubmed/30951587
     
  11. Shide K, Kameda T, Kamiunten A, Oji A, Ozono Y, Sekine M, Honda A, Kitanaka A, Akizuki K, Tahira Y, Nakamura K, Hidaka T, Kubuki Y, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Hasuike S, Yamamoto S, Nagata K, Ikawa M, *Shimoda K.
    Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis.
    Blood Cancer J. 2019 Mar 29;9(4):42.
    https://www.ncbi.nlm.nih.gov/pubmed/30926777
     
  12. §Noda T, §Sakurai N, Nozawa K, Kobayashi S, Devlin DJ, *Matzuk MM, *Ikawa M.
    §: equal contribution
    Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice.
    Andrology. 2019 Sep;7(5):644-653.
    https://www.ncbi.nlm.nih.gov/pubmed/30927342
     
  13. Tobita T, Kiyozumi D, Muto M, Noda T, *Ikawa M.
    Lvrn expression is not critical for mouse placentation.
    J Reprod Dev. 2019 Jun 14;65(3):239-244.
    "https://www.ncbi.nlm.nih.gov/pubmed/30745494
     
  14. Noda T, Fujihara Y, Matsumura T, Oura S, Kobayashi S, *Ikawa M.
    Seminal vesicle secretory protein 7, PATE4, is not required for sperm function but for copulatory plug formation to ensure fecundity.
    Biol Reprod.2019 Apr 19;100(4):1035-1045
    https://www.ncbi.nlm.nih.gov/pubmed/30452524
     
  15. Shimada K, Kato H, Miyata H, *Ikawa M.
    Glycerol kinase 2 is essential for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during mouse spermatogenesis.
    J Reprod Dev. 2019 Apr 12;65(2):155-162.
    https://www.ncbi.nlm.nih.gov/pubmed/30662012
     
  16. Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, He Z, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, *Okamoto T, *Matsuura Y.
    USP15 participates in HCV propagation through the regulation of viral RNA translation and lipid droplet formation.
    J Virol. 2019 Mar 5;93(6). pii: e01708-18.
    https://www.ncbi.nlm.nih.gov/pubmed/30626683
     
  17. Matsumura T, Endo T, Isotani A, Ogawa M, *Ikawa M.
    An Azoospermic Factor gene, Ddx3y and its paralog, Ddx3x are dispensable in germ cells for male fertility.
    J Reprod Dev. 2019 Apr 12;65(2):121-128.
    https://www.ncbi.nlm.nih.gov/pubmed/30613052
     
  18. Senoo M, Takijiri T, Yoshida N, Ozawa M, *Ikawa M.
    PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia.
    J Reprod Dev. 2019 Feb 8;65(1):37-46.
    https://www.ncbi.nlm.nih.gov/pubmed/30416150 

  19. Oura S, Miyata H, Noda T, Shimada K, Matsumura T, Morohoshi A, Isotani A, *Ikawa M.
    Chimeric analysis with newly established EGFP/DsRed2-tagged ES cells identify HYDIN as essential for spermiogenesis in mice.
    Exp Anim. 2019 Feb 26;68(1):25-34.
    https://www.ncbi.nlm.nih.gov/pubmed/30089752

  20. Kimura H, Yamamoto H, Harada T, Fumoto K, Osugi Y, Sada R, Maehara N, Hikita H, Mori S, Eguchi H, Ikawa M, Takehara T, *Kikuchi A.
    CKAP4, a DKK1 receptor, is a biomarker in exosomes derived from pancreatic cancer and a molecular target for therapy.
    Clin Cancer Res. 2019 Jan 4. pii: clincanres.2124.2018.
    https://www.ncbi.nlm.nih.gov/pubmed/30610103 

  21. Sato Y, Kiyozumi D, Futaki S, Nakano I, Shimono C, Kaneko N, Ikawa M, Okabe M, Sawamoto K, *Sekiguchi K.
    Ventricular-subventricular zone fractones are speckled basement membranes that function as a neural stem cell niche.
    Mol Biol Cell. 2019 Jan 1;30(1):56-68.
    https://www.ncbi.nlm.nih.gov/pubmed/30379609