Oura S, Ninomiya A, Sugihara F, Matzuk MM, #Ikawa M.
Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins. Sci Rep. 2022 Dec 23;12(1):22198. doi: 10.1038/s41598-022-26501-7. https://pubmed.ncbi.nlm.nih.gov/36564444/
#Harada YU, Amo H, Ono T, Murai H, Sasaki T, Shioda T, Ikawa M, Hirata Y.
Inactivation of SARS-CoV-2 by Commercially Available Disinfectants and Cleaners. Biocontrol Sci.2022;27(4):223-228. doi: 10.4265/bio.27.223. https://pubmed.ncbi.nlm.nih.gov/36567119/
#Ozawa M, Taguchi J, Katsuma K, Ishikawa-Yamauchi Y, Kikuchi M, Sakamoto R, Yamada Y, #Ikawa M.
Efficient simultaneous double DNA knock-in in murine embryonic stem cells by CRISPR/Cas9 ribonucleoprotein-mediated circular plasmid targeting for generating gene-manipulated mice. Sci Rep.2022 Dec 13;12(1):21558. doi: 10.1038/s41598-022-26107-z. https://pubmed.ncbi.nlm.nih.gov/36513736/
Iida-Norita R, Miyata H, Kaneda Y, Emori C, Noda T, Nakagawa T, #Matzuk MM, #Ikawa M.
Generation of humanized LDHC knock-in mice as a tool to assess human LDHC-targeting contraceptive drugs. Andrology. 2022 Dec 4. doi: 10.1111/andr.13359. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36464740/
Sakurai N, #Fujihara Y, Kobayashi K, Ikawa M.
CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male sub-fertility in mice. Andrology. 2022 Nov 25. doi: 10.1111/andr.13350. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36428102/
#Lu Y, #Ikawa M.
Eukaryotic fertilization and gamete fusion at a glance. J Cell Sci. 2022 Nov 15;135(22):jcs260296. doi: 10.1242/jcs.260296. Epub 2022 Nov 23. https://pubmed.ncbi.nlm.nih.gov/36416181/
Yokoyama M, Fujita T, Kadonosawa Y, Tatara Y, Motooka D, Ikawa M, Fujii H, #Yokoayama Y.
Development of transgenic mice overexpressing mouse carbonyl reductase 1. Mol Biol Rep. 2022 Nov 9. doi: 10.1007/s11033-022-07994-x. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36352178/
Oura S, Mori H, #Ikawa M.
Genome editing in mice and its application to the study of spermatogenesis. Gene and Genome Editing. Available online 30 October 2022, 100014
Nozawa K, Garcia TX, Kent K, Leng M, Jain A, Malovannaya A, Yuan F, Yu Z, Ikawa M, #Matzuk MM.
Testis-specific serine kinase 3 is required for sperm morphogenesis and male fertility. Andrology. 2022 Oct 28. doi: 10.1111/andr.13314. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36306217/
#Fujihara Y, Kobayashi K, Abbasi F, Endo T, Yu Z, Ikawa M, Matzuk MM.
PDCL2 is essential for sperm acrosome formation and male fertility in mice. Andrology. 2022 Oct 24. doi: 10.1111/andr.13329. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/36278277/
*Tang S, *Lu Y, Skinner WM, Sanyal M, Lishko PV, #Ikawa M, #Kim PS.
Human sperm TMEM95 binds eggs and facilitates membrane fusion. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2207805119. doi: 10.1073/pnas.2207805119. Epub 2022 Sep 26. https://pubmed.ncbi.nlm.nih.gov/36161911/
Hashimoto R, Takahashi J, Shirakura K, Funatsu R, Kosugi K, Deguchi S, Yamamoto M, Tsunoda Y, Morita M, Muraoka K, Tanaka M, Kanbara T, Tanaka S, Tamiya S, Tokunoh N, Kawai A, Ikawa M, Ono C, Tachibana K, Kondoh M, Obana M, Matsuura Y, Ohsumi A, Noda T, Yamamoto T, Yoshioka Y, Torisawa YS, Date H, Fujio Y, Nagao M, #Takayama K, #Okada Y.
SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression. Sci Adv. 2022 Sep 23;8(38):eabo6783. doi: 10.1126/sciadv.abo6783. Epub 2022 Sep 21. https://pubmed.ncbi.nlm.nih.gov/36129989/
Irie M, Itoh J, Matsuzawa A, Ikawa M, Kiyonari H, Kihara M, Suzuki T, Hiraoka Y, #Ishino F, #Kaneko-Ishino T.
Retrovirus-derived RTL5 and RTL6 genes are novel constituents of the innate immune system in the eutherian brain. Development. 2022 Sep 15;149(18):dev200976. doi: 10.1242/dev.200976. Epub 2022 Sep 27. https://pubmed.ncbi.nlm.nih.gov/36162816/
Vondrakova J, Frolikova M, Ded L, Cerny J, Postlerova P, Palenikova V, Simonik O, Nahacka Z, Basus K, Valaskova E, Machan R, Pacey A, Holubcova Z, Koubek P, Ezrova Z, Park S, Liu R, Partha R, Clark N, Neuzil J, Ikawa M, Erickson K, Lam KS, #Moore H, #Komrskova K.
MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization. Sci Adv. 2022 Sep 9;8(36):eabn0047. doi: 10.1126/sciadv.abn0047. Epub 2022 Sep 7. https://pubmed.ncbi.nlm.nih.gov/36070373/
#Kobayashi D, Watarai T, Ozawa M, Kanda Y, Saika F, Kiguchi N, Takeuchi A, Ikawa M, Matsuzaki S, #Katakai T.
Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway. Front Immunol. 2022 Aug 18;13:973880. doi: 10.3389/fimmu.2022.973880. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/36059440/
Nozawa K, Fujihara Y, Devlin DJ, Deras RE, Kent K, Larina IV, Umezu K, Yu Z, Sutton CM, Ye Q, Dean LK, Emori C, Ikawa M, Garcia TX, #Matzuk MM.
The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. BMC Biol. 2022 Jul 13;20(1):161. doi: 10.1186/s12915-022-01368-2. https://pubmed.ncbi.nlm.nih.gov/35831855/
#Fujiki F, Morimoto S, Katsuhara A, Okuda A, Ogawa S, Ueda E, Miyazaki M, Isotani A, Ikawa M, Nishida S, Nakajima H, Tsuboi A, Oka Y, Nakata J, Hosen N, Kumanogoh A, Oji Y, #Sugiyama H.
T Cell-Intrinsic Vitamin A Metabolism and Its Signaling Are Targets for Memory T Cell-Based Cancer Immunotherapy. Front Immunol. 2022 Jun 30;13:935465. doi: 10.3389/fimmu.2022.935465. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35844620/
Kuwayama R, Suzuki K, Nakamura J, Aizawa E, Yoshioka Y, Ikawa M, Nabatame S, Inoue KI, Shimmyo Y, Ozono K, Kinoshita T, #Murakami Y.
Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy. Nat Commun. 2022 Jun 3;13(1):3107. doi: 10.1038/s41467-022-30847-x. https://pubmed.ncbi.nlm.nih.gov/35661110/
Oura S, Hino T, Satoh T, Noda T, Koyano T, Isotani A, Matsuyama M, Akira S, Ishiguro KI, #Ikawa M.
Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. PLoS Genet. 2022 Jun 1;18(6):e1010241. doi: 10.1371/journal.pgen.1010241. eCollection 2022 Jun. https://pubmed.ncbi.nlm.nih.gov/35648791/
Kaneda Y, #Miyata H, Shimada K, Oyama Y, Iida-Norita R, #Ikawa M.
IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice. Dev Biol. 2022 May 23:S0012-1606(22)00099-9. doi: 10.1016/j.ydbio.2022.05.011. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35618043/
Oyama Y, #Miyata H, Shimada K, Larasati T, Fujihara Y, #Ikawa M
TULP2 deletion mice exhibit abnormal outer dense fiber structure and male infertility. Reprod Med Biol. 2022 May 23;21(1):e12467. doi: 10.1002/rmb2.12467. eCollection Jan-Dec 2022. https://pubmed.ncbi.nlm.nih.gov/35619658/
Oyama Y, #Miyata H, Shimada K, Fujihara Y, Tokuhiro K, Garcia TX, Matzuk MM, #Ikawa M.
CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Asian J Androl. 2022 May- Jun;24(3):266-272. doi: 10.4103/aja.aja_63_21. https://pubmed.ncbi.nlm.nih.gov/34290169/
Noda T, Blaha A, Fujihara Y, Gert KR, Emori C, Deneke VE, Oura S, Panser K, Lu Y, Berent S, Kodani M, Cabrera-Quio LE, #Pauli A, #Ikawa M.
Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish. Commun Biol. 2022 Apr 7;5(1):332. doi: 10.1038/s42003-022-03289-w. https://pubmed.ncbi.nlm.nih.gov/35393517/
Hiramatsu Y, Suzuki K, Nishida T, Onoda N, Satoh T, Akira S, Ikawa M, Ikeda H, Kamei J, Derouiche S, Tominaga M, #Horiguchi Y.
The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model. mBio.2022 Mar 31;e0319721. doi: 10.1128/mbio.03197-21. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35357202/
El Hussien MA, Tsai CY, Satouh Y, Motooka D, Okuzaki D, Ikawa M, #Kikutani H, #Sakakibara S.
Corrigendum to: Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice. Int Immunol.2022 Mar 25;34(4):225. doi: 10.1093/intimm/dxac007. https://pubmed.ncbi.nlm.nih.gov/35348696/
Yamauchi Y, Matsumura T, Bakse J, Holmlund H, Blanchet G, Carrot E, Ikawa M, #Ward MA.
Loss of mouse Y chromosome gene Zfy1 and Zfy2 leads to spermatogenesis impairment, sperm defects, and infertility. Biol Reprod. 2022 Mar 16;ioac057. doi: 10.1093/biolre/ioac057. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35293998/
Mise S, #Matsumoto A, Shimada K, Hosaka T, Takahashi M, Ichihara K, Shimizu H, Shiraishi C, Saito D, Suyama M, Yasuda T, Ide T, Izumi Y, Bamba T, Kimura-Someya T, Shirouzu M, Miyata H, Ikawa M, #Nakayama KI.
Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis. Nat Commun. 2022 Feb 28;13(1):1071. doi: 10.1038/s41467-022-28677-y. https://pubmed.ncbi.nlm.nih.gov/35228556/
Hirata T, Kobayashi A, Furuse T, Yamada I, Tamura M, Tomita H, Tokoro Y, Ninomiya A, Fujihara Y, Ikawa M, Maeda Y, Murakami Y, #Kizuka Y, #Kinoshita T.
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. J Biol Chem. 2022 Mar;298(3):101720. doi: 10.1016/j.jbc.2022.101720. Epub 2022 Feb 11. https://pubmed.ncbi.nlm.nih.gov/35151686/
#Miyata H, Oyama Y, Kaneda Y, #Ikawa M.
The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum. Exp Anim. 2022 Feb 9;71(1):46-52. doi: 10.1538/expanim.21-0082. Epub 2021 Sep 15. https://pubmed.ncbi.nlm.nih.gov/34526446/
Matsumura T, Noda T, Satouh Y, Morohoshi A, Yuri S, Ogawa M, Lu Y, Isotani A, #Ikawa M.
Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Front Cell Dev Biol. 2022 Jan 12;9:810118. doi: 10.3389/fcell.2021.810118. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/35096839/
Hwang JY, Wang H, Lu Y, Ikawa M, #Chung JJ.
C2cd6-encoded CatSperτ targets sperm calcium channel to Ca 2+ signaling domains in the flagellar membrane. Cell Rep. 2022 Jan 18;38(3):110226. doi: 10.1016/j.celrep.2021.110226. Epub 2022 Jan 7. https://pubmed.ncbi.nlm.nih.gov/34998468