原著論文 Original Articles

2016年

  1. Lee GH, Fujita M, Takaoka K, Murakami Y, Fujihara Y, Kanzawa N, Murakami KI, Kajikawa E, Takada Y, Saito K, Ikawa M, Hamada H, Maeda Y, *Kinoshita T.
    A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO.
    J Cell Biol. 2016 Dec 5;215(5):705-718.
    http://www.ncbi.nlm.nih.gov/pubmed/27881714  
     
  2. Young SA, Miyata H, Satouh Y, Aitken RJ, Baker MA, *Ikawa M.
    CABYR is essential for fibrous sheath integrity and progressive motility in mouse spermatozoa.
    J Cell Sci. 2016 Dec 1;129(23):4379-4387.
    http://www.ncbi.nlm.nih.gov/pubmed/27802166  
     
  3. Young SA, Miyata H, Satouh Y, Muto M, Larsen MR, Aitken RJ, Baker M, *Ikawa M.
    CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility.
    Reproduction.2016 Dec;152(6):665-672.
    http://www.ncbi.nlm.nih.gov/pubmed/27624483  
     
  4. Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, *Seya T.
    STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.
    Biochem Biophys Res Commun.2016 Sep 30;478(4):1764-71.
    http://www.ncbi.nlm.nih.gov/pubmed/27608599  
     
  5. Oji A, Noda T, Fujihara Y, Miyata H, Kim YJ, Muto M, Nozawa K, Matsumura T, Isotani A, *Ikawa M.
    CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice.
    Sci Rep. 2016 Aug 17;6:31666.
    http://www.ncbi.nlm.nih.gov/pubmed/27530713  
     
  6. Kato K, Satouh Y, Nishimasu H, Kurabayashi A, Morita J, Fujihara Y, Oji A, Ishitani R, *Ikawa M, *Nureki O.
    Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization.
    Nat Commun. 2016 Jul 15;7:12198.
    http://www.ncbi.nlm.nih.gov/pubmed/27416963
    微生物病研究所 「主な研究成果」 紹介ページへ  
     
  7. *Shimada M, Goshima T, Matsuo H, Johmura Y, Haruta M, Murata K, Tanaka H, Ikawa M, Nakanishi K, *Nakanishi M.
    Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis.
    Nat Commun. 2016 Jul 8;7:12059.
    http://www.ncbi.nlm.nih.gov/pubmed/27389782  
     
  8. Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, *Ikawa M, *Matzuk MM.
    Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice.
    Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7704-10.
    http://www.ncbi.nlm.nih.gov/pubmed/27357688
    微生物病研究所 「主な研究成果」 紹介ページへ  
     
  9. Kanemori Y, Koga Y, Sudo M, Kang W, Kashiwabara SI, Ikawa M, Hasuwa H, Nagashima K, Ishikawa Y, Ogonuki N, Ogura A, *Baba T.
    Biogenesis of sperm acrosome is regulated by pre-mRNA alternative splicing of Acrbp in the mouse.
    Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3696-705.
    http://www.ncbi.nlm.nih.gov/pubmed/27303034
    外部紹介ページへ  
     
  10. Yamazaki D, Funato Y, Miyata H, Ikawa M, *Miki H.
    Complementary role of CNNM2 in sperm motility and Ca2+ influx during capacitation.
    Biochem Biophys Res Commun. 2016 Jun 3;474(3):441-6.
    http://www.ncbi.nlm.nih.gov/pubmed/27150626  
     
  11. Shimbo M, *Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami KI, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TK, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S.
    Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.
    Exp Anim. 2016 May 20;65(2):175-87.
    http://www.ncbi.nlm.nih.gov/pubmed/26822934  
     
  12. Yamazaki D, Miyata H, Funato Y, Fujihara Y, Ikawa M, *Miki H.
    The Mg2+ transporter CNNM4 regulates sperm Ca2+ homeostasis and it is essential for reproduction.
    J Cell Sci. 2016 May 1;129(9):1940-9.
    http://www.ncbi.nlm.nih.gov/pubmed/27006114  
     
  13. Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, Seto M, *Matsuura K, *Moriyama M.
    Kidney-specific knockout of Sav1 in the mouse promotes hyper-proliferation of renal tubular epithelium through suppression of the Hippo pathway.
    J Pathol. 2016 May;239(1):97-108.
    http://www.ncbi.nlm.nih.gov/pubmed/26913567  
     
  14. *Isotani A, Yamagata K, Okabe M, Ikawa M.
    Generation of Hprt-disrupted rat through mouse←rat ES chimeras.
    Sci Rep. 2016 Apr 11;6:24215.
    http://www.ncbi.nlm.nih.gov/pubmed/27062982  
     
  15. Muro Y, Hasuwa H, Isotani A, Miyata H, Yamagata K, Ikawa M, Yanagimachi R, *Okabe M.
    Behavior of Mouse Spermatozoa in the Female Reproductive Tract from Soon after Mating to the Beginning of Fertilization.
    Biol Reprod. 2016 Apr;94(4):80.
    http://www.ncbi.nlm.nih.gov/pubmed/26962112  
     
  16. Brukman NG, Miyata H, Torres P, Lombardo D, Caramelo JJ, Ikawa M, Da Ros VG, *Cuasnicú PS.
    Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: Implications for fertility disorders.
    Mol Hum Reprod. 2016 Apr;22(4):240-51.
    http://www.ncbi.nlm.nih.gov/pubmed/26786179  
     
  17. Muto M, Fujihara Y, Tobita T, Kiyozumi D, *Ikawa M.
    Lentiviral Vector Mediated Complementation Restored Fetal Viability but Not Placental hyperplasia in Plac1-Deficient Mice.
    Biol Reprod. 2016 Jan;94(1):6.
    http://www.ncbi.nlm.nih.gov/pubmed/26586843