原著論文 Original Articles

2017年

  1. Abe S, Kobayashi K, Oji A, Sakuma T, Kazuki T, Takehara S, Nakamura K, Okada A, Tsukazaki Y, Senda N, Honma K, Yamamoto T, Ikawa M, Chiba K, Oshimura M, *Kazuki Y.
    Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.
    Sci Rep. 2017 Nov 9;7(1):15189
    https://www.ncbi.nlm.nih.gov/pubmed/29123154 
     
  2. Fujihara Y, Oji A, Larasati T, Kojima-Kita K, *Ikawa M.
    Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse Models.
    Int J Mol Sci. Oct 21;18(10):2208.
    https://www.ncbi.nlm.nih.gov/pubmed/29065458
     
  3. *Mashiko D, Ikawa M, *Fujimoto K.
    Mouse spermatozoa with higher fertilization rates have thinner nuclei.
    PeerJ 2017 Oct 5:e3913.
    https://www.ncbi.nlm.nih.gov/pubmed/29038763
     
  4. Honda M, Hidaka K, Fukada SI, Sugawa R, Shirai M, Ikawa M, *Morisaki T.
    Vestigial-like 2 contributes to normal muscle fiber type distribution in mice.
    Sci Rep. Aug 2;7(1):7168.
    https://www.ncbi.nlm.nih.gov/pubmed/28769032
     
  5. *Isotani A, Matsumura T, Ogawa M, Tanaka T, Yamagata K, Ikawa M, Okabe M.
    A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats.
    Biol Reprod. 2017 Jul 1;97(1):61-68.
    https://www.ncbi.nlm.nih.gov/pubmed/28859281

     
  6. Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R , Yu Z, Ramirez-Solis R, *Ikawa M, *Matzuk MM, *Liu M
    TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa.
    Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5370-E5378.
    https://www.ncbi.nlm.nih.gov/pubmed/28630322
    微生物病研究所 「主な研究成果」 紹介ページへ  
     
  7. *Ishimoto K, Ikawa M, *Okabe, M.
    The mechanics clarifying counterclockwise rotation in most IVF eggs in mice.
    Sci Rep. 2017 Mar 3;7:43456.
    https://www.ncbi.nlm.nih.gov/pubmed/?term=28256541
     
  8. Satouh Y, Nozawa K, Yamagata K, Fujimoto T, *Ikawa M.
    Viable offspring after imaging of Ca2+ oscillations and visualization of the cortical reaction in mouse eggs.
    Biol Reprod. 2017 Mar 1;96(3):563-575.
    https://www.ncbi.nlm.nih.gov/pubmed/28339615
     
  9. Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, *Asano M.
    New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice.
    FASEB J. 2017 Jun;31(6):2252-2266.
    https://www.ncbi.nlm.nih.gov/pubmed/28188179
    外部紹介ページへ  
     
  10. Onda K, *Tong S, Beard S, Binder N, Muto M, Senadheera SN, Parry L, Dilworth M, Renshall L, Brownfoot F, Hastie R, Tuohey L, Palmer K, Hirano T, Ikawa M, Kaitu'u-Lino T, Hannan NJ.
    Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction.
    Hypertension. 2017 Mar;69(3):457-468.
    http://www.ncbi.nlm.nih.gov/pubmed/28115513
     
  11. Fujimoto K, Kinoshita M, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Tamura A, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, *Takeda K.
    Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.
    Mucosal Immunol. 2017 Mar;10(2):446-459.
    http://www.ncbi.nlm.nih.gov/pubmed/27381925 
     
  12. *Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, *Yamagata K.
    Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
    Cell Rep. 2017 Jan 17;18(3):593-600.
    http://www.ncbi.nlm.nih.gov/pubmed/28099840
     
  13. Ishikawa T, *Kitaura Y, Kadota Y, Morishita Y, Ota M, Yamanaka F, Xu M, Ikawa M, Inoue N, Kawano F, Nakai N, Murakami T, Miura S, Hatazawa Y, Kamei Y, *Shimomura Y.
    Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition.
    Sci Rep. 2017 Jan 4;7:39825.
    http://www.ncbi.nlm.nih.gov/pubmed/28051178